A ratiometric fluorescent probe for detection of exogenous mitochondrial SO2 based on a FRET mechanism

被引：24

作者：

Xu, Zhiyang ^{[1
]}

Chen, Zhen ^{[1
]}

Liu, Aikun ^{[1
]}

Ji, Ruixue ^{[1
]}

Cao, Xiaoqun ^{[1
]}

Ge, Yanqing ^{[1
]}

机构：

[1] Taishan Med Univ, Sch Chem & Pharmaceut Engn, Tai An 271000, Shandong, Peoples R China

来源：

RSC ADVANCES | 2019年 / 9卷 / 16期

关键词：

SULFUR-DIOXIDE DERIVATIVES; ENDOGENOUSLY GENERATED SO2; SELECTIVE DETECTION; OPTICAL-PROPERTIES; RAPID DETECTION; BISULFITE; SULFITE; HG2+; FLUOROPHORE; INDOLIZINE;

D O I：

10.1039/c8ra10328c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel imidazo[1,5-a]pyridine-hemicyanine based ratiometric fluorescent probe for detection of mitochondrial SO2 was designed and synthesized. The probe is based on a fluorescence resonance energy transfer (FRET) mechanism. It exhibits high selectivity and sensitivity towards SO32- with a fast response time (3 min) and detection limit of 0.13 M. Further, it showed low cytotoxicity and was successfully applied to image exogenous mitochondrial SO2 in cells.

引用

页码：8943 / 8948

页数：6

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