Sensitization of hypervigilance effects of cocaine can be induced by NK3 receptor activation in marmoset monkeys

被引:7
|
作者
Melamed, Jonathan L. [1 ]
Silva, Maria A. de Souza [2 ]
Tomaz, Carlos [3 ,4 ]
Mueller, Christian P. [5 ]
Huston, Joseph P. [2 ]
Barros, Marilia [1 ]
机构
[1] Univ Brasilia, Sch Hlth Sci, Dept Pharmaceut Sci, BR-70910900 Brasilia, DF, Brazil
[2] Univ Dusseldorf, Ctr Behav Neurosci, Inst Expt Psychol, D-40025 Dusseldorf, Germany
[3] Univ Brasilia, Ctr Primate, BR-70910900 Brasilia, DF, Brazil
[4] Univ Brasilia, Inst Biol, Dept Physiol Sci, BR-70910900 Brasilia, DF, Brazil
[5] Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, Sect Addict Med, D-91054 Erlangen, Germany
关键词
Marmoset; Cocaine; Sensitization; Vigilance; NK3; receptor; Senktide; TACHYKININ NK-3 RECEPTORS; SUBSTANCE-P; ALCOHOL INTAKE; BEHAVIORAL SENSITIZATION; GENE-EXPRESSION; ADDICTION; LOCALIZATION; VIGILANCE; PHARMACOLOGY; TRANSMISSION;
D O I
10.1016/j.drugalcdep.2012.08.020
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Background: Cocaine is a widely abused drug which can result in the establishment of addiction. The neurokinin3-receptor (NO-R) has been linked to cocaine addiction by genetic, epigenetic, and pharmacological studies suggesting that a cocaine-induced increase in NK3-R signaling may contribute to the establishment of cocaine addiction-related behaviors. Methods: Here we measured cocaine-induced sensitization of vigilance- and locomotor behaviors in marmoset monkeys (Callithrix penicillata) in an open field. Results: We found a sensitization of vigilance-related, but not locomotor behaviors after repeated cocaine (7 mg/kg, i.p.) treatment. There was a cross-sensitization for scan frequency, but not of glance frequency, both vigilance-related behaviors, after repeated treatment with the NK3-R agonist senktide (0.2 mg/kg, i.p.) given for 7 days, after a cocaine challenge (5 mg/kg, i.p.). Conclusions: These data suggest that in marmoset monkeys, repeated cocaine treatment leads to a sensitization of vigilance-related behaviors, which have a prominent role in spontaneously expressed activities in this species, but not of locomotor activity. Repeated activation of NK3-Rs can mimic some of the behavioral sensitization effect and may thus contribute to the establishment of cocaine related behaviors. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:155 / 160
页数:6
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