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Sensitization of hypervigilance effects of cocaine can be induced by NK3 receptor activation in marmoset monkeys
被引:7
|作者:
Melamed, Jonathan L.
[1
]
Silva, Maria A. de Souza
[2
]
Tomaz, Carlos
[3
,4
]
Mueller, Christian P.
[5
]
Huston, Joseph P.
[2
]
Barros, Marilia
[1
]
机构:
[1] Univ Brasilia, Sch Hlth Sci, Dept Pharmaceut Sci, BR-70910900 Brasilia, DF, Brazil
[2] Univ Dusseldorf, Ctr Behav Neurosci, Inst Expt Psychol, D-40025 Dusseldorf, Germany
[3] Univ Brasilia, Ctr Primate, BR-70910900 Brasilia, DF, Brazil
[4] Univ Brasilia, Inst Biol, Dept Physiol Sci, BR-70910900 Brasilia, DF, Brazil
[5] Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, Sect Addict Med, D-91054 Erlangen, Germany
关键词:
Marmoset;
Cocaine;
Sensitization;
Vigilance;
NK3;
receptor;
Senktide;
TACHYKININ NK-3 RECEPTORS;
SUBSTANCE-P;
ALCOHOL INTAKE;
BEHAVIORAL SENSITIZATION;
GENE-EXPRESSION;
ADDICTION;
LOCALIZATION;
VIGILANCE;
PHARMACOLOGY;
TRANSMISSION;
D O I:
10.1016/j.drugalcdep.2012.08.020
中图分类号:
R194 [卫生标准、卫生检查、医药管理];
学科分类号:
摘要:
Background: Cocaine is a widely abused drug which can result in the establishment of addiction. The neurokinin3-receptor (NO-R) has been linked to cocaine addiction by genetic, epigenetic, and pharmacological studies suggesting that a cocaine-induced increase in NK3-R signaling may contribute to the establishment of cocaine addiction-related behaviors. Methods: Here we measured cocaine-induced sensitization of vigilance- and locomotor behaviors in marmoset monkeys (Callithrix penicillata) in an open field. Results: We found a sensitization of vigilance-related, but not locomotor behaviors after repeated cocaine (7 mg/kg, i.p.) treatment. There was a cross-sensitization for scan frequency, but not of glance frequency, both vigilance-related behaviors, after repeated treatment with the NK3-R agonist senktide (0.2 mg/kg, i.p.) given for 7 days, after a cocaine challenge (5 mg/kg, i.p.). Conclusions: These data suggest that in marmoset monkeys, repeated cocaine treatment leads to a sensitization of vigilance-related behaviors, which have a prominent role in spontaneously expressed activities in this species, but not of locomotor activity. Repeated activation of NK3-Rs can mimic some of the behavioral sensitization effect and may thus contribute to the establishment of cocaine related behaviors. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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页码:155 / 160
页数:6
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