TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

被引：150

作者：

Tsai, Vicky Wang-Wei ^{[1
,2
]}

Macia, Laurence ^{[3
]}

Johnen, Heiko ^{[1
,2
]}

Kuffner, Tamara ^{[1
,2
]}

Manadhar, Rakesh ^{[1
,2
]}

Jorgensen, Sebastian Beck ^{[4
]}

Lee-Ng, Ka Ki Michelle ^{[1
,2
]}

Zhang, Hong Ping ^{[1
,2
]}

Wu, Liyun ^{[1
,2
]}

Marquis, Christopher Peter ^{[5
]}

Jiang, Lele ^{[1
,2
]}

Husaini, Yasmin ^{[1
,2
]}

Lin, Shu ^{[3
]}

Herzog, Herbert ^{[3
]}

Brown, David A. ^{[1
,2
]}

Sainsbury, Amanda ^{[3
]}

Breit, Samuel N. ^{[1
,2
]}

机构：

[1] St Vincents Hosp, St Vincents Ctr Appl Med Res, Sydney, NSW 2010, Australia

[2] Univ New S Wales, Sydney, NSW, Australia

[3] Garvan Inst Med Res, Neurosci Program, Sydney, NSW, Australia

[4] Novo Nordisk AS, Diabet Res Unit, Malov, Denmark

[5] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW, Australia

来源：

PLOS ONE | 2013年 / 8卷 / 02期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

MACROPHAGE INHIBITORY CYTOKINE-1; GROWTH-DIFFERENTIATION FACTOR-15; BONE MORPHOGENETIC PROTEIN-7; FACTOR-BETA SUPERFAMILY; DIET-INDUCED OBESITY; BROWN ADIPOGENESIS; SERUM; MIC-1; INDIVIDUALS; DIAGNOSIS;

D O I：

10.1371/journal.pone.0055174

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of physiologically relevant levels of MIC-1/GDF15 in the regulation of appetite, body weight and basal metabolic rate. MIC-1/GDF15 gene knockout mice (MIC-1(-/-)) weighed more and had increased adiposity, which was associated with increased spontaneous food intake. Female MIC-1(-/-) mice exhibited some additional alterations in reduced basal energy expenditure and physical activity, possibly owing to the associated decrease in total lean mass. Further, infusion of human recombinant MIC-1/GDF15 sufficient to raise serum levels in MIC-1(-/-) mice to within the normal human range reduced body weight and food intake. Taken together, our findings suggest that MIC-1/GDF15 is involved in the physiological regulation of appetite and energy storage.

引用

页数：10

共 19 条

[1] Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE-/- mice from the development of atherosclerosis
Johnen, Heiko
Kuffner, Tamara
Brown, David A.
Wu, Ben J.
Stocker, Roland
Breit, Samuel N.
CARDIOVASCULAR PATHOLOGY, 2012, 21 (06) : 499 - 505
[2] Anorexia-cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15
Tsai, V. W. W.
Lin, S.
Brown, D. A.
Salis, A.
Breit, S. N.
INTERNATIONAL JOURNAL OF OBESITY, 2016, 40 (02) : 193 - 197
[3] Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity
Tsai, V. W.
Zhang, H. P.
Manandhar, R.
Lee-Ng, K. K. M.
Lebhar, H.
Marquis, C. P.
Husaini, Y.
Sainsbury, A.
Brown, D. A.
Breit, S. N.
INTERNATIONAL JOURNAL OF OBESITY, 2018, 42 (03) : 561 - 571
[4] Anorexia/cachexia of chronic diseases: a role for the TGF-β family cytokine MIC-1/GDF15
Tsai, Vicky W. W.
Husaini, Yasmin
Manandhar, Rakesh
Lee-Ng, K. K. Michelle
Zhang, Hong Ping
Harriott, Kate
Jiang, Lele
Lin, Shu
Sainsbury, Amanda
Brown, David A.
Breit, Samuel N.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2012, 3 (04) : 239 - 243
[5] MIC-1/GDF15 in Barrett's oesophagus and oesophageal adenocarcinoma
Fisher, O. M.
Levert-Mignon, A. J.
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Lee-Ng, K. K. M.
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Breit, S. N.
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BRITISH JOURNAL OF CANCER, 2015, 112 (08) : 1384 - 1391
[6] The Anorectic Actions of the TGFβ Cytokine MIC-1/GDF15 Require an Intact Brainstem Area Postrema and Nucleus of the Solitary Tract
Tsai, Vicky Wang-Wei
Manandhar, Rakesh
Jorgensen, Sebastian Beck
Lee-Ng, Ka Ki Michelle
Zhang, Hong Ping
Marquis, Christopher Peter
Jiang, Lele
Husaini, Yasmin
Lin, Shu
Sainsbury, Amanda
Sawchenko, Paul E.
Brown, David A.
Breit, Samuel N.
PLOS ONE, 2014, 9 (06):
[7] MIC-1/GDF15 in Barrett’s oesophagus and oesophageal adenocarcinoma
O M Fisher
A J Levert-Mignon
S J Lord
K K M Lee-Ng
N K Botelho
D Falkenback
M L Thomas
Y V Bobryshev
D C Whiteman
D A Brown
S N Breit
R V Lord
British Journal of Cancer, 2015, 112 : 1384 - 1391
[8] A Prospective Study of Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) and Risk of Colorectal Cancer
Mehta, Raaj S.
Song, Mingyang
Bezawada, Navya
Wu, Kana
Garcia-Albeniz, Xabier
Morikawa, Teppei
Fuchs, Charles S.
Ogino, Shuji
Giovannucci, Edward L.
Chan, Andrew T.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2014, 106 (04):
[9] Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease
Breit, Samuel N.
Carrero, Juan J.
Tsai, Vicky Wang-Wei
Yagoutifam, Nasreen
Luo, Wei
Kuffner, Tamara
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Wu, Liyun
Jiang, Lele
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Heimburger, Olof
Murikami, Mary-Ann
Apple, Fred S.
Marquis, Christopher P.
Macia, Laurence
Lin, Shu
Sainsbury, Amanda
Herzog, Herbert
Law, Matthew
Stenvinkel, Peter
Brown, David A.
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2012, 27 (01) : 70 - 75
[10] Macrophage inhibitory cytokine 1 (MIC-1/GDF15) as a novel diagnostic serum biomarker in pancreatic ductal adenocarcinoma
Wang, Xiaobing
Li, Yanfen
Tian, Haimei
Qi, Jun
Li, Mo
Fu, Chao
Wu, Fan
Wang, Yi
Cheng, Dongwan
Zhao, Wenya
Zhang, Chao
Wang, Teng
Rao, Jianyu
Zhang, Wei
BMC CANCER, 2014, 14

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