Toluene Abuse and White Matter A Model of Toxic Leukoencephalopathy

被引：25
作者：
Filley, Christopher M. [1 ]
机构：
[1] Univ Colorado, Sch Med, Behav Neurol Sect, Aurora, CO 80045 USA
来源：
PSYCHIATRIC CLINICS OF NORTH AMERICA | 2013年 / 36卷 / 02期
关键词：
Toluene; White matter; Dementia; Toxic; Leukoencephalopathy; Inhalants; BRAIN; INHALANT; ABNORMALITIES; ADOLESCENTS; PATHWAYS; EXPOSURE; SOLVENTS;
D O I：
10.1016/j.psc.2013.02.008
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The brain is the primary target of toluene (methylbenzene), the major solvent in spray paint and a constituent of many other easily obtained commercial and industrial products. The effects of acute intoxication can be dramatic and the lasting adverse effects of inhalants may be highly injurious. Mental status alterations range from acute confusional state to coma. Toluene abuse effects on white matter are demonstrable neuroradiologically and neuropathologically, and have important neurobehavioral consequences.
引用
收藏
页码：293 / +
页数：11
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共 50 条
[1]   Brain damage in a large cohort of solvent abusers [J].
Al-Hajri, Zahra ;
Del Bigio, Marc R. .
ACTA NEUROPATHOLOGICA, 2010, 119 (04) :435-445
[2]   REGIONAL BRAIN DISTRIBUTION OF TOLUENE IN RATS AND IN A HUMAN AUTOPSY [J].
AMENO, K ;
KIRIU, T ;
FUKE, C ;
AMENO, S ;
SHINOHARA, T ;
IJIRI, I .
ARCHIVES OF TOXICOLOGY, 1992, 66 (02) :153-156
[3]  
[Anonymous], 2006, FIBER PATHWAYS BRAIN, DOI DOI 10.1093/ACPROF:OSO/9780195104233.003.0014
[4]   Association, commissural, and projection pathways and their functional deficit reported in literature [J].
Aralasmak, Ayse ;
Ulmer, John L. ;
Kocak, Mehmet ;
Salvan, Carmen V. ;
Hillis, Argye E. ;
Yousem, David M. .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 2006, 30 (05) :695-715
[5]  
Aydin K, 2002, AM J NEURORADIOL, V23, P1173
[6]   Single-voxel proton MR spectroscopy in toluene abuse [J].
Aydin, K ;
Sencer, S ;
Ogel, K ;
Genchellac, H ;
Demir, T ;
Minareci, O .
MAGNETIC RESONANCE IMAGING, 2003, 21 (07) :777-785
[7]  
Bartzokis G, 2005, ADOLESCENT PSYCHIAT, V29, P55
[8]   Biology of oligodendrocyte and myelin in the mammalian central nervous system [J].
Baumann, N ;
Pham-Dinh, D .
PHYSIOLOGICAL REVIEWS, 2001, 81 (02) :871-927
[9]   Oligodendrocytes Susceptibility to injury and involvement in neurologic disease [J].
Benarroch, Eduardo E. .
NEUROLOGY, 2009, 72 (20) :1779-1785
[10]  
Brouette T, 2001, AM J ADDICTION, V10, P79
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