CHANGES IN THE PLATELET FUNCTIONAL CHARACTERISTICS IN PLATELET CONCENTRATES AFTER INACTIVATION OF PATHOGENS (preliminary communication)

被引：0

作者：

Nakastoev, I. M. ^{[1
]}

Grachev, A. E. ^{[1
]}

Gemdzhyan, E. G. ^{[1
]}

Panteleev, M. A. ^{[1
]}

Zakharova, N. V. ^{[1
]}

Vatagina, E. A. ^{[1
]}

Kastrikina, I. S. ^{[1
]}

Pogorelov, V. M. ^{[1
]}

Ryzhko, V. V. ^{[1
]}

机构：

[1] Hematol Res Ctr, Moscow, Russia

来源：

GEMATOLOGIYA I TRANSFUZIOLOGIYA | 2012年 / 57卷 / 05期

关键词：

platelet concentrate; pathogen inactivation. amotosalen; P-selectin; phosphatidylserine; APHERESIS PLATELETS; SPRINT TRIAL; BACTERIAL-CONTAMINATION; AMOTOSALEN-HCL; TRANSFUSION; EXPERIENCE; LIGHT;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of the study was evaluation of the effects of amotosalen photodynamic inactivation of pathogens in platelet concentrates (PC) on the platelet function. Three groups of PC were analyzed: 1) native PC on the day of donation; 2) native PC after 20-24 h storage; and 3) PC after pathogen inactivation (PI) by the Intercept system 20-24 h after donation. Platelet counts, large and immature platelet fractions, phosphatidylserine (PS) and P-selection expression on inactivated platelet membranes and after their target stimulation were studied in all samples. Pathogen inactivation was associated with a significant reduction of platelet concentrations in PC. Studies of PS and P-selectin expression showed that PI suppressed spontaneous stimulation of platelets during storage. However, direct stimulation of platelets was associated with a significant reduction of PS expression in PC subjected to PI. The PI method used in our study led to reduction of cell concentrations in PC and modulated platelet function.

引用

页码：32 / 36

页数：5

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