Pharmacogenomic Control of Angiotensin Converting Enzyme Gene I/D Polymorphism - Predominant Risk Factor of Development of Chronic Heart Failure and Target of Enalapril Treatment

被引：0

作者：

Teplyakov, A. T. ^{[1
]}

Shilov, S. N. ^{[1
]}

Berezikova, E. N. ^{[1
]}

Efremov, A. V. ^{[1
]}

Safronov, I. D. ^{[1
]}

Pustovetova, M. G. ^{[1
]}

Mayanskaya, S. D. ^{[1
]}

Torim, Yu. Yu. ^{[1
]}

Karpov, R. S. ^{[1
]}

机构：

[1] Res Inst Cardiol SB RAMS, Tomsk 634012, Russia

来源：

KARDIOLOGIYA | 2013年 / 53卷 / 03期

关键词：

heart failure; ischemic heart disease; genetic polymorphism; angiotensin converting enzyme; enalapril; INSERTION/DELETION POLYMORPHISM; BLOOD-PRESSURE; SYSTEM; INHIBITORS; IMPACT;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim of investigation - to study effect of angiotensin-converting enzyme (ACE) gene polymorphism as a dominant risk factor of development of chronic heart failure (CHF) and target for effective therapy with ACE inhibitor enalapril in patients with ischemic heart disease. We followed 226 patients with CHF on stable permanent basic therapy comprising beta-adrenoblocker, diuretic, aldosterone antagonist, digoxin, and ACE inhibitor. Seventy eight patients received enalapril (starting dose 2.5 mg twice daily with subsequent titration up to 10-20 mg twice daily). Control group comprised 136 patients without cardiovascular abnormalities. Allele D of polymorphic locus I/D of ACE gene in homozygous state was associated with high risk of development and severity of clinical manifestations of CHF. In patients with DID genotype of ACE gene at the background of therapy with enelapril we noted more pronounced lowering of CHF functional class and augmentation of left ventricular ejection fraction compared with patients having I/I and I/D genotypes. We revealed associative interrelationships of ACE gene polymorphism (polymorphic locus I/D) with development and severity of CHF as well as effectiveness of therapy with an ACE inhibitor enalapril.

引用

页码：9 / 14

页数：6

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