Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii

被引：233

作者：

Koblansky, A. Alicia ^{[1
]}

Jankovic, Dragana ^{[3
]}

Oh, Hyunju ^{[1
]}

Hieny, Sara ^{[3
]}

Sungnak, Waradon ^{[1
]}

Mathur, Ramkumar ^{[1
]}

Hayden, Matthew S. ^{[1
,2
]}

Akira, Shizuo ^{[4
]}

Sher, Alan ^{[3
]}

Ghosh, Sankar ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Microbiol & Immunol, New York, NY 10032 USA

[2] Columbia Univ Coll Phys & Surg, Dept Dermatol, New York, NY 10032 USA

[3] NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[4] Osaka Univ, WPI Immunol Frontier Res Ctr, Lab Host Def, Suita, Osaka 5650871, Japan

来源：

IMMUNITY | 2013年 / 38卷 / 01期

关键词：

DENDRITIC CELLS; CUTTING EDGE; INTERFERON-GAMMA; IFN-GAMMA; IL-12; PRODUCTION; ACUTE INFECTION; STRANDED-RNA; PARASITE; INTERLEUKIN-12; ACTIVATION;

D O I：

10.1016/j.immuni.2012.09.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptor 11 (TLR11) recognizes T. gondii profilin (TgPRF) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii-infected mice. However, TLR11 only modestly affects survival of T. gondii-challenged mice. We report that TLR12, a previously uncharacterized TLR, also recognized TgPRF. TLR12 was sufficient for recognition of TgPRF by plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 were both required in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice succumb rapidly to T. gondii infection. TLR12-dependent induction of IL-12 and IFN-alpha in pDCs led to production of IFN-gamma by NK cells. Consistent with this observation, the partial resistance of Tlr11(-/-) mice is lost upon pDC or NK cell depletion. Thus, TLR12 is critical for the innate immune response to T. gondii, and this TLR may promote host resistance by triggering pDC and NK cell function.

引用

页码：119 / 130

页数：12

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