Ferrocenyl analogues of bisacodyl: Synthesis and antimicrobial activity

被引：12

作者：

Goermen, Meral ^{[1
]}

Veitia, Maite Sylla-Iyarreta ^{[1
]}

Trigui, Fatma ^{[2
]}

El Arbi, Mehdi ^{[2
]}

Ferroud, Clotilde ^{[1
]}

机构：

[1] Cnam, Equipe Chim Mol, Lab CMGPCE, EA 7341, F-75003 Paris, France

[2] Univ Sfax, LBMIE, Ctr Biotechnol Sfax, Sfax 3018, Tunisia

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2015年 / 794卷

关键词：

Bisacodyl; Ferrocene; Antibacterial; PYRIDINE N-OXIDE; IN-VITRO; ANTIBACTERIAL ACTIVITIES; ANTITUBERCULAR ACTIVITY; BIOLOGICAL EVALUATION; ANTI-HIV-1; AGENTS; CCR5; ANTAGONISTS; DRUG DISCOVERY; DERIVATIVES; ANTIMALARIAL;

D O I：

10.1016/j.jorganchem.2015.07.016

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The antibacterial activity of bisacodyl, a drug used in therapeutic as laxative is described herein for the first time. Ten original ferrocenyl analogues have been synthesized via an efficient synthetic procedure using the McMurry coupling reaction. The antibacterial activity was investigated against Gram-positive and Gram-negative foodborne pathogens including Listeria monocytogenes, Escherichia coli, Enterococcus faecalis, Salmonella enterica, Micrococcus luteus and Staphylococcus aureus. The results showed that most of these compounds exhibit an excellent antimicrobial activity, and the bisacodyl analogues seemed to be more bactericides than bacteriostatic. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：274 / 281

页数：8

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