Gli Proteins: Regulation in Development and Cancer

被引：151

作者：

Niewiadomski, Pawel ^{[1
]}

Niedziolka, Sylwia M. ^{[1
]}

Markiewicz, Lukasz ^{[1
]}

Uspienski, Tomasz ^{[1
]}

Baran, Brygida ^{[1
]}

Chojnowska, Katarzyna ^{[1
]}

机构：

[1] Univ Warsaw, Ctr New Technol, Banacha 2c, PL-02097 Warsaw, Poland

来源：

CELLS | 2019年 / 8卷 / 02期

关键词：

Hedgehog signaling; Gli proteins; posttranslational modifications; primary cilia; cancer; developmental signaling; morphogen signaling; nuclear import; HEDGEHOG SIGNALING PATHWAY; NEURAL STEM-CELL; NUCLEAR-LOCALIZATION SIGNAL; TRANSCRIPTION FACTOR GLI1; CILIARY PORE COMPLEX; HUMAN COLON-CANCER; SONIC-HEDGEHOG; PANCREATIC-CANCER; PRIMARY CILIUM; KINASE-A;

D O I：

10.3390/cells8020147

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer. We review the molecular mechanisms of Gli protein regulation in mammals, with special emphasis on posttranslational modifications and intracellular transport. We also discuss how Gli proteins interact with co-activators and co-repressors to fine-tune the expression of Hedgehog target genes. Finally, we provide an overview of the regulation of developmental processes and tissue regeneration by Gli proteins and discuss how these proteins are involved in cancer progression, both through canonical regulation via the Hedgehog pathway and through cross-talk with other signaling pathways.

引用

页数：36

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