Aconitate hydratase of mammals under oxidative stress

被引：26
作者：
Matasova, L. V. [1 ]
Popova, T. N. [1 ]
机构：
[1] Voronezh State Univ, Voronezh 394006, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2008年 / 73卷 / 09期
关键词：
aconitase; citrate; oxidative stress; iron; iron-regulatory proteins; regulation of activity and expression;
D O I：
10.1134/S0006297908090010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Data on the structure, functions, regulation of activity, and expression of cytosolic and mitochondrial aconitate hydratase isoenzymes of mammals are reviewed. The role of aconitate hydratase and structurally similar iron-regulatory protein in maintenance of homeostasis of cell iron is described. Information on modifications of the aconitate hydratase molecule and changes in expression under oxidative stress is generalized. The role of aconitate hydratase in the pathogenesis of some diseases is considered.
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收藏
页码：957 / 964
页数：8
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