Collagen α-tocopherulate for topical applications: Preparation, characterization, and antioxidant activity evaluation

被引：5

作者：

Trombino, Sonia ^{[1
]}

Cassano, Roberta ^{[1
]}

Ferrarelli, Teresa ^{[1
]}

Isacchi, Benedetta ^{[2
]}

Bilia, Anna Rita ^{[2
]}

Picci, Nevio ^{[1
]}

机构：

[1] Univ Calabria, Dept Pharmaceut Sci, I-87036 Cosenza, Italy

[2] Univ Florence, Dept Pharmaceut Sci, I-50019 Florence, Italy

来源：

MACROMOLECULAR RESEARCH | 2012年 / 20卷 / 09期

关键词：

solid phase synthesis; alpha-tocopherol protein conjugate; antioxidant activity; SCAFFOLDS;

D O I：

10.1007/s13233-012-0129-8

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The aim of this work was to synthesize collagen alpha-tocopherulate for topical treatments. Collagen is a natural polymer largely applied to enhance wound repair, and alpha-tocopherol is a known antioxidant used for the treatment of various skin diseases. Linking the two through covalent bonds could improve alpha-tocopherol transport and metabolic stability, reduce the rate of degradation, and ensure a longer persistence than free antioxidant. The new biopolymer was prepared by a solid-phase synthesis employing a carboxypolystyrene resin. Its antioxidant activity in rat liver microsomal membranes was also evaluated. The obtained collagen-based biomaterial represents a new prodrug of alpha-tocopherol that could be used for various biomedical applications.

引用

页码：939 / 943

页数：5

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