Vasoreactivity before and after handgrip training in chronic heart failure patients

被引:16
作者
Credeur, Daniel P. [2 ]
Mariappan, Nithya [3 ]
Francis, Joseph [1 ]
Thomas, David [4 ]
Moraes, Denzil [4 ]
Welsch, Michael A. [1 ]
机构
[1] Louisiana State Univ, Dept Kinesiol, Baton Rouge, LA 70803 USA
[2] Univ Missouri, Columbia, MO USA
[3] Pennington Biomed Res Ctr, Baton Rouge, LA USA
[4] Our Lady Lake Reg Med Ctr, Baton Rouge, LA USA
关键词
Vasodilation; Vasoconstriction; Ultrasonography; Exercise; FLOW-MEDIATED DILATION; CORONARY-ARTERY-DISEASE; ENDOTHELIAL FUNCTION; BRACHIAL-ARTERY; VASCULAR FUNCTION; EXERCISE; HUMANS; ADAPTATIONS; REACTIVITY; GUIDELINES;
D O I
10.1016/j.atherosclerosis.2012.08.013
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The purpose of this study was to investigate the vasodilatory and vasoconstrictor responses of the brachial artery in patients with chronic heart failure (CHF) and controls (CON) before and after a period of training and detraining. Methods: CHF (n = 10; age = 62 +/- 8 yrs) and CON (n = 10; age = 55 +/- 5 yrs) subjects completed 4 weeks of bilateral handgrip training (20 min; 60% of maximal handgrip strength; 15 grips*min(-1); 4 days*week(-1)). Handgrip strength was measured using a hand dynamometer. Brachial artery flow-mediated dilation (BAFMD) and cold pressor test (CPT) responses were determined using ultrasonography prior to training, at the end of 4 weeks of training and following 4 weeks of detraining. Absolute (mm) BAFMD and CPT responses were combined to yield a vascular operating range (VOR). Results: Baseline BAFMD was higher in CON (CHF: 2.98 +/- 1.49%; CON: 6.21 +/- 1.21%; p = 0.01), while CPT responses were higher in CHF (CHF: 3.38 +/- 0.83%; CON: 2.46 +/- 0.62%; p = 0.05). Baseline VOR tended to be greater in the CON subjects (CHF: 0.28 +/- 0.05 mm; CON: 0.32 +/- 0.12 mm; p = 0.06). Training increased handgrip strength (similar to 5%; p < 0.05, for both groups), BAFMD (CHF: 2.98 +/- 1.49% to 3.75 +/- 1.56%; CON: 6.21 +/- 1.21% - 8.02 +/- 1.75%; p = 0.01) and VOR (CHF: 0.28 +/- 0.05 mm - 0.3 +/- 0.09 mm; CON: 0.32 +/- 0.12 mm - 0.42 +/- 0.11 mm; p = 0.01). There were no significant changes in CPT responses. All markers approached pre-training values following detraining. Conclusion: Handgrip exercise increases strength, BAFMD and VOR in both CHF and CON subjects. These improvements are transient and return to pre-training values after removal of the training stimulus. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:154 / 159
页数:6
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