Sequential alpha-interferon and tamoxifen: In vitro biologic effects of two growth modulators

被引：0
作者：
Seymour, L [1 ]
Bezwoda, WR [1 ]
机构：
[1] UNIV WITWATERSRAND,DEPT MED,DIV CLIN HAEMATOL & MED ONCOL,ZA-2050 WITWATERSRAND,SOUTH AFRICA
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1997年 / 10卷 / 06期
关键词：
breast cancer; tamoxifen; interferon; MCF-7; modulation; growth factors; estrogen receptor;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tamoxifen and alpha-interferon have interesting and complementary biologic effects which may be relevant for breast cancer growth and regression. The hormone responsive cell line MCF-7 was used as a model to study the biologic effects of sequential administration of these two agents. Interferon had a significant antiproliferative effect and increased ER and TGF-beta expression. The combination had at least additive antiproliferative effects as well as effects on expression of ER, TGF-beta, c-erbB-2, P24 and Ki67. alpha-IFN modulates TMX induced biologic effects and the sequential administration of alpha-IFN and TMX may lead to potentially important modulation of biologic endpoints. Further studies are appropriate.
引用
收藏
页码：1277 / 1282
页数：6
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共 34 条
  • [11] STIMULATION OF GROWTH OF HUMAN BREAST-CANCER CELLS (T47D) BY PLATELET DERIVED GROWTH-FACTOR
    GINSBURG, E
    VONDERHAAR, BK
    [J]. CANCER LETTERS, 1991, 58 (1-2) : 137 - 144
  • [12] GOLDSTEIN D, 1989, CANCER RES, V49, P2698
  • [13] BIDIRECTIONAL INTERACTIONS BETWEEN THE ESTROGEN-RECEPTOR AND THE C-ERBB-2 SIGNALING PATHWAYS - HEREGULIN INHIBITS ESTROGENIC EFFECTS IN BREAST-CANCER CELLS
    GRUNT, TW
    SACEDA, M
    MARTIN, MB
    LUPU, R
    DITTRICH, E
    KRUPITZA, G
    HARANT, H
    HUBER, H
    DITTRICH, C
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1995, 63 (04) : 560 - 567
  • [14] INGLE JN, 1994, CANCER-AM CANCER SOC, V73, P2337, DOI 10.1002/1097-0142(19940501)73:9<2337::AID-CNCR2820730916>3.0.CO
  • [15] 2-Q
  • [16] ERBB-2 ONCOPROTEIN OVEREXPRESSION IN BREAST-CARCINOMA - INVERSE CORRELATION WITH BIOCHEMICALLY-DETERMINED AND IMMUNOHISTOCHEMICALLY-DETERMINED HORMONE RECEPTORS
    KESHGEGIAN, AA
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 1995, 35 (02) : 201 - 210
  • [17] HUMAN MAMMARY-TUMOR CELL-PROLIFERATION - PRIMARY ROLE OF PLATELET-DERIVED GROWTH-FACTOR AND POSSIBLE SYNERGISM WITH HUMAN ALPHA-FETOPROTEIN
    LEAL, JA
    GANGRADE, BK
    KISER, JL
    MAY, JV
    KEEL, BA
    [J]. STEROIDS, 1991, 56 (05) : 247 - 251
  • [18] INFLUENCE OF HORMONES ON TUMOR-GROWTH, CELL-KINETICS, ESTROGEN-RECEPTOR AND INSULIN-LIKE GROWTH FACTOR-I-RELATED PROTEIN OF HUMAN BREAST-CANCER (MCF-7) CELLS TRANSPLANTED IN NUDE-MICE
    NOGUCHI, M
    THOMAS, M
    KOYASAKI, N
    OHTA, N
    TANIYA, T
    KITAGAWA, H
    MIYAZAKI, I
    MIZUKAMI, Y
    [J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1993, 92 (01) : 69 - 76
  • [19] RELATIONSHIP BETWEEN TAMOXIFEN-INDUCED TRANSFORMING GROWTH-FACTOR BETA(1) EXPRESSION, CYTOSTASIS AND APOPTOSIS IN HUMAN BREAST-CANCER CELLS
    PERRY, RR
    KANG, Y
    GREAVES, BR
    [J]. BRITISH JOURNAL OF CANCER, 1995, 72 (06) : 1441 - 1446
  • [20] Determination of ErbB2 protein in breast cancer tissues by different methods. Relationships with other biological parameters
    Piffanelli, A
    Dittadi, R
    Catozzi, L
    Gion, M
    Capitanio, G
    Gelli, MC
    Brazzale, A
    Malagutti, R
    Pelizzola, D
    Menegon, A
    Giovannini, G
    Gardini, G
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 1996, 37 (03) : 267 - 276
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