Accurate pH Sensing using Hyperpolarized 129Xe NMR Spectroscopy

被引：15

作者：

Leonce, Estelle ^{[1
]}

Dognon, Jean-Pierre ^{[1
]}

Pitrat, Delphine ^{[2
]}

Mulatier, Jean-Christophe ^{[2
]}

Brotin, Thierry ^{[2
]}

Berthault, Patrick ^{[1
]}

机构：

[1] Univ Paris Saclay, CEA Saclay, CNRS, NIMBE,CEA, F-91191 Gif Sur Yvette, France

[2] Ecole Normale Super Lyon, UMR 5182, Lab Chim, ENS LYON, 46 Allee Italie, F-69364 Lyon 07, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2018年 / 24卷 / 25期

关键词：

cryptophanes; hyperpolarized xenon; NMR spectroscopy; pH mapping; quantum chemistry; WATER-SOLUBLE CRYPTOPHANES; BIOSENSOR; SENSORS; XENON;

D O I：

10.1002/chem.201800900

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the search for powerful non-invasive methods for pH measurement, NMR usually suffers from biases, especially for heterogeneous samples or tissues. In this Communication, using the signals of hyperpolarized Xe-129 encapsulated in a pair of water-soluble cryptophanes, we show that a differential pH measurement can be achieved, free from most of these biases, by monitoring the difference between their chemical shifts.

引用

页码：6534 / 6537

页数：4

共 17 条

[1] The NMR chemical shift pH measurement revisited: Analysis of error and modeling of a pH dependent reference [J].

Ackerman, JJH ;

Soto, GE ;

Spees, WM ;

Zhu, ZH ;

Evelhoch, JL .

MAGNETIC RESONANCE IN MEDICINE, 1996, 36 (05) :674-683

[2] Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer [J].

Adams, Ralph W. ;

Aguilar, Juan A. ;

Atkinson, Kevin D. ;

Cowley, Michael J. ;

Elliott, Paul I. P. ;

Duckett, Simon B. ;

Green, Gary G. R. ;

Khazal, Iman G. ;

Lopez-Serrano, Joaqun ;

Williamson, David C. .

SCIENCE, 2009, 323 (5922) :1708-1711

[3] Effect of pH and Counterions on the Encapsulation Properties of Xenon in Water-Soluble Cryptophanes [J].

Berthault, Patrick ;

Desvaux, Herve ;

Wendlinger, Thierry ;

Gyejacquot, Marina ;

Stopin, Antoine ;

Brotin, Thierry ;

Dutasta, Jean-Pierre ;

Boulard, Yves .

CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (43) :12941-12946

[4] Influence of the Chemical Structure of Water-Soluble Cryptophanes on Their Overall Chiroptical and Binding Properties [J].

Bouchet, Aude ;

Brotin, Thierry ;

Linares, Mathieu ;

Cavagnat, Dominique ;

Buffeteau, Thierry .

JOURNAL OF ORGANIC CHEMISTRY, 2011, 76 (19) :7816-7825

[5] Ultrafast Z-Spectroscopy for 129Xe NMR-Based Sensors [J].

Boutin, Celine ;

Leonce, Estelle ;

Brotin, Thierry ;

Jerschow, Alexej ;

Berthault, Patrick .

JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2013, 4 (23) :4172-4176

[6] Improved synthesis of functional CTVs and cryptophanes using Sc(OTf)3 as catalyst [J].

Brotin, T ;

Roy, V ;

Dutasta, JP .

JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (16) :6187-6195

[7] WATER-SOLUBLE CRYPTOPHANE BINDING LIPOPHILIC GUESTS IN AQUEOUS-SOLUTION [J].

CANCEILL, J ;

LACOMBE, L ;

COLLET, A .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (03) :219-221

[8] Cryptophanols, new versatile compounds for the synthesis of functionalized cryptophanes and polycryptophanes [J].

Darzac, M ;

Brotin, T ;

Bouchu, D ;

Dutasta, JP .

CHEMICAL COMMUNICATIONS, 2002, (01) :48-49

[9] Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate [J].

Gallagher, Ferdia A. ;

Kettunen, Mikko I. ;

Day, Sam E. ;

Hu, De-En ;

Ardenkjær-Larsen, Jan Henrik ;

in't Zandt, Rene ;

Jensen, Pernille R. ;

Karlsson, Magnus ;

Golman, Klaes ;

Lerche, Mathilde H. ;

Brindle, Kevin M. .

NATURE, 2008, 453 (7197) :940-U73

[10] PH imaging [J].

Gillies, RJ ;

Raghunand, N ;

Garcia-Martin, ML ;

Gatenby, RA .

IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, 2004, 23 (05) :57-64

← 1 2 →