Radiogenomics : Using Genetics to Identify Cancer Patients at Risk for Development of Adverse Effects Following Radiotherapy

被引：89

作者：

Kerns, Sarah L. ^{[1
,6
]}

Ostrer, Harry ^{[6
,7
]}

Rosenstein, Barry S. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Radiat Oncol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Dermatol, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Dept Prevent Med, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA

[5] NYU, Sch Med, Dept Radiat Oncol, New York, NY USA

[6] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA

[7] Albert Einstein Coll Med, Dept Genet & Pediat, Bronx, NY 10467 USA

来源：

CANCER DISCOVERY | 2014年 / 4卷 / 02期

关键词：

GENOME-WIDE ASSOCIATION; SINGLE-NUCLEOTIDE POLYMORPHISMS; PROSTATE-CANCER; NORMAL TISSUE; RADIATION-THERAPY; COMPLICATION PROBABILITY; LINKAGE DISEQUILIBRIUM; ERECTILE DYSFUNCTION; IONIZING-RADIATION; DATA METAANALYSIS;

D O I：

10.1158/2159-8290.CD-13-0197

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Normal-tissue adverse effects following radiotherapy are common and significantly affect quality of life. These effects cannot be accounted for by dosimetric, treatment, or demographic factors alone, and evidence suggests that common genetic variants are associated with radiotherapy adverse effects. The field of radiogenomics has evolved to identify such genetic risk factors. Radiogenomics has two goals: (i) to develop an assay to predict which patients with cancer are most likely to develop radiation injuries resulting from radiotherapy, and (ii) to obtain information about the molecular pathways responsible for radiation-induced normal-tissue toxicities. This review summarizes the history of the field and current research. Significance: A single-nucleotide polymorphism-based predictive assay could be used, along with clinical and treatment factors, to estimate the risk that a patient with cancer will develop adverse effects from radiotherapy. Such an assay could be used to personalize therapy and improve quality of life for patients with cancer. (C) 2014 AACR.

引用

页码：155 / 165

页数：11

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