Regulation of mucin genes in chronic inflammatory airway diseases

被引：150
作者：
Voynow, Judith A. [1 ]
Gendler, Sandra J.
Rose, Mary C.
机构：
[1] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA
[2] Mayo Clin & Mayo Fdn, Coll Med, Dept Biochem Mol Biol, Scottsdale, AZ USA
[3] Mayo Clin & Mayo Fdn, Coll Med, Tumor Biol Program, Scottsdale, AZ USA
[4] George Washington Univ, Childrens Natl Med Ctr, Res Ctr Genet Med, Washington, DC USA
[5] George Washington Univ, Dept Pediat, Washington, DC 20052 USA
[6] George Washington Univ, Dept Biochem Mol Biol, Washington, DC 20052 USA
来源：
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 2006年 / 34卷 / 06期
关键词：
D O I：
10.1165/rcmb.2006-0035SF
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review, we summarize work over the past 15 years on mucin gene expression and regulation in the lung, as well as how mucin gene expression is altered in chronic lung diseases. This field owes a great debt to Carol Basbaum for her pioneering work in dissecting signaling pathways regulating mucin gene expression and for her tremendous energy in promoting the importance of understanding the basic pathogenic mechanisms that drive mucus overproduction in cystic fibrosis, chronic obstructive pulmonary disease, and asthma.
引用
收藏
页码：661 / 665
页数：5
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