Matrix Metalloproteinase-9 Expression by Hodgkin-Reed-Sternberg Cells Is Associated with Reduced Overall Survival in Young Adult Patients with Classical Hodgkin Lymphoma

被引：7

作者：

Campos, Antonio Hugo ^{[1
]}

Vassallo, Jose ^{[1
,2
]}

Soares, Fernando Augusto ^{[1
]}

机构：

[1] AC Camargo Canc Care Ctr, Dept Anat Pathol, Sao Paulo, Brazil

[2] Univ Estadual Campinas, Fac Med Sci, Lab Invest & Mol Pathol CIPED, Campinas, SP, Brazil

来源：

PLOS ONE | 2013年 / 8卷 / 09期

基金：

巴西圣保罗研究基金会;

关键词：

EPSTEIN-BARR-VIRUS; NITRIC-OXIDE SYNTHASES; MEMBRANE-PROTEIN; MATRIX METALLOPROTEINASES; DISEASE; CANCER; ICAM-1; ACTIVATION; INFECTION; PREDICTS;

D O I：

10.1371/journal.pone.0074793

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Previous studies have investigated the prognostic relevance of MMP9 in classical Hodgkin lymphoma (cHL), with negative results. However, we have found that MMP9 immunoistochemical expression by Hodgkin-Reed-Sternberg cells is associated with reduced overall survival in a subset of young adult Brazilian patients diagnosed with cHL. Additionally, we have observed that MMP9 expression by neoplastic cells in cHL is associated with EBV positivity. These results may support a rational basis for additional studies on the role of this metalloproteinase as a target for therapy in classical Hodgkin lymphoma.

引用

页数：6

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