HSP90α combined with AFP and TK1 improved the diagnostic value for hepatocellular carcinoma

被引：16

作者：

Tang, Yanping ^{[1
]}

Li, Kezhi ^{[1
]}

Cai, Zhengmin ^{[1
]}

Xie, Yuxuan ^{[1
]}

Tan, Xiaoyu ^{[1
]}

Su, Chenglin ^{[1
]}

Li, Jilin ^{[1
]}

机构：

[1] Guangxi Med Univ, Dept Res, Canc Hosp, Nanning 530021, Guangxi, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 10期

关键词：

alpha-fetoprotein; AUC; biomarker; combination; diagnostic value; heat shock protein 90 alpha; hepatocellular carcinoma; retrospective study; sensitivity; specificity; thymidine kinase 1; SHOCK-PROTEIN; 90-ALPHA; COLORECTAL-CANCER; ALPHA-FETOPROTEIN; EXTRACELLULAR HSP90-ALPHA; REGULATORY MECHANISM; THYMIDINE KINASE; EXPRESSION; HSP90; MIGRATION; BIOMARKER;

D O I：

10.2217/bmm-2019-0484

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: We investigated the effect of the combination of heat shock protein 90 alpha (HSP90 alpha), alpha-fetoprotein (AFP) and thymidine kinase 1 (TK1) in the diagnosis of hepatocellular carcinoma (HCC). Methods & results: A total of 409 patients with HCC, 101 patients with benign liver disorder and 78 healthy individuals were retrospectively analyzed. HSP90 alpha level was higher in HCC patients than in controls. The expression of HSP90a showed a positive correlation with tumor stage, differentiation, lymph node metastasis and tumor thrombus formation. The combination of HSP90 alpha, AFP and TK1 improved the diagnostic sensitivity (89.24%) and the area under the receiver operating characteristic curve (0.919). Conclusion: The detection of HSP90 alpha, AFP and TK1 is more efficient than a single tumor marker for the diagnosis of HCC.

引用

页码：869 / 878

页数：10

共 34 条

[1]

[Anonymous], CA CANCER J CLIN

[2] Thymidine kinase and cancer monitoring [J].

Aufderklamm, Stefan ;

Todenhoefer, Tilman ;

Gakis, Georgios ;

Kruck, Stephan ;

Hennenlotter, Joerg ;

Stenzl, Arnulf ;

Schwentner, Christian .

CANCER LETTERS, 2012, 316 (01) :6-10

[3] HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization [J].

Azoitei, Ninel ;

Diepold, Kristina ;

Brunner, Cornelia ;

Rouhi, Arefeh ;

Genze, Felicitas ;

Becher, Alexander ;

Kestler, Hans ;

van Lint, Johan ;

Chiosis, Gabriela ;

Koren, John, III ;

Froehling, Stefan ;

Scholl, Claudia ;

Seufferlein, Thomas .

CANCER RESEARCH, 2014, 74 (23) :7125-7136

[4] Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases [J].

Becker, B ;

Multhoff, G ;

Farkas, B ;

Wild, PJ ;

Landthaler, M ;

Stolz, W ;

Vogt, T .

EXPERIMENTAL DERMATOLOGY, 2004, 13 (01) :27-32

[5] The landscape of somatic copy-number alteration across human cancers [J].

Beroukhim, Rameen ;

Mermel, Craig H. ;

Porter, Dale ;

Wei, Guo ;

Raychaudhuri, Soumya ;

Donovan, Jerry ;

Barretina, Jordi ;

Boehm, Jesse S. ;

Dobson, Jennifer ;

Urashima, Mitsuyoshi ;

Mc Henry, Kevin T. ;

Pinchback, Reid M. ;

Ligon, Azra H. ;

Cho, Yoon-Jae ;

Haery, Leila ;

Greulich, Heidi ;

Reich, Michael ;

Winckler, Wendy ;

Lawrence, Michael S. ;

Weir, Barbara A. ;

Tanaka, Kumiko E. ;

Chiang, Derek Y. ;

Bass, Adam J. ;

Loo, Alice ;

Hoffman, Carter ;

Prensner, John ;

Liefeld, Ted ;

Gao, Qing ;

Yecies, Derek ;

Signoretti, Sabina ;

Maher, Elizabeth ;

Kaye, Frederic J. ;

Sasaki, Hidefumi ;

Tepper, Joel E. ;

Fletcher, Jonathan A. ;

Tabernero, Josep ;

Baselga, Jose ;

Tsao, Ming-Sound ;

Demichelis, Francesca ;

Rubin, Mark A. ;

Janne, Pasi A. ;

Daly, Mark J. ;

Nucera, Carmelo ;

Levine, Ross L. ;

Ebert, Benjamin L. ;

Gabriel, Stacey ;

Rustgi, Anil K. ;

Antonescu, Cristina R. ;

Ladanyi, Marc ;

Letai, Anthony .

NATURE, 2010, 463 (7283) :899-905

[6] Secreted Heat Shock Protein 90α Induces Colorectal Cancer Cell Invasion through CD91/LRP-1 and NF-κB-mediated Integrin αV Expression [J].

Chen, Jinn-Shiun ;

Hsu, Yuan-Ming ;

Chen, Chia-Chi ;

Chen, Li-Li ;

Lee, Chun-Chung ;

Huang, Tze-Sing .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (33) :25458-25466

[7] Cancer Statistics in China, 2015 [J].

Chen, Wanqing ;

Zheng, Rongshou ;

Baade, Peter D. ;

Zhang, Siwei ;

Zeng, Hongmei ;

Bray, Freddie ;

Jemal, Ahmedin ;

Yu, Xue Qin ;

He, Jie .

CA-A CANCER JOURNAL FOR CLINICIANS, 2016, 66 (02) :115-132

[8] Secreted Heat Shock Protein 90α (HSP90α) Induces Nuclear Factor-κB-mediated TCF12 Protein Expression to Down-regulate E-cadherin and to Enhance Colorectal Cancer Cell Migration and Invasion [J].

Chen, Wei-Shone ;

Chen, Chia-Chi ;

Chen, Li-Li ;

Lee, Chun-Chung ;

Huang, Tze-Sing .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (13) :9001-9010

[9] Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness [J].

Eustace, BK ;

Sakurai, T ;

Stewart, JK ;

Yimlamai, D ;

Unger, C ;

Zehetmeier, C ;

Lain, B ;

Torella, C ;

Henning, SW ;

Beste, G ;

Scroggins, BT ;

Neckers, L ;

Ilag, LL ;

Jay, DG .

NATURE CELL BIOLOGY, 2004, 6 (06) :507-514

[10] Plasma Heat Shock Protein 90alpha as a Biomarker for the Diagnosis of Liver Cancer: An Official, Large-scale, and Multicenter Clinical Trial [J].

Fu, Yan ;

Xu, Xiao ;

Huang, Dongsheng ;

Cui, Dawei ;

Liu, Lisheng ;

Liu, Junwei ;

He, Zenglei ;

Liu, Jingjing ;

Zheng, Shusen ;

Luo, Yongzhang .

EBIOMEDICINE, 2017, 24 :56-63

← 1 2 3 4 →