Radiofrequency Ablation of Liver Tumors: No Difference in the Ablation Zone Volume Between Cirrhotic and Healthy Liver

被引:20
作者
Cassinotto, Christophe [1 ]
Denys, Alban [2 ]
Gay, Frederique [2 ]
Duran, Rafael [2 ]
Hocquelet, Arnaud [2 ]
Piron, Lauranne [1 ]
Guiu, Boris [1 ]
机构
[1] St Eloi Univ Hosp, Dept Radiol, Montpellier, France
[2] CHU Vaudois, Dept Radiol, Off BH10-119,Rue Bugnon 46, CH-1011 Lausanne, Switzerland
关键词
Liver neoplasms; Hepatocellular carcinoma; Liver metastasis; Percutaneous radiofrequency ablation; Interventional radiology; SMALL HEPATOCELLULAR-CARCINOMA; THERMAL ABLATION; 5-YEAR SURVIVAL; RISK-FACTORS; MANAGEMENT; RESECTION; SOLITARY; OUTCOMES;
D O I
10.1007/s00270-018-1898-z
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose The "oven effect" theory assumes that radiofrequency ablation (RFA) would be more efficient on tumors of cirrhotic livers. The aim of the study was to compare the size and volume of the ablation zone following RFA on tumors of cirrhotic versus healthy livers. Methods One hundred and eleven patients who underwent RFA from 2011 to 2013 for the treatment of 140 liver tumors (83 hepatocellular carcinomas developed on a cirrhotic liver, i.e., "cirrhosis group," and 57 tumors developed on a healthy liver, mainly liver metastasis, i.e., "healthy liver group") using the same RFA device were retrospectively selected. The diameter and volume of the ablation zone were compared between groups at the end of the procedure (FUO), at first (FU1) and second follow-up (FU2) performed 1.6 months (+/- 19 days) and 4.7 months (+/- 40 days) post-RFA, respectively. Results No differences in the size or volume of the ablation zone were found between groups at FUO (36.5 +/- 12 mm vs. 34.3 +/- 10 mm, p = 0.5; and 28 +/- 16 mm(3) vs. 26.5 +/- 16 mm (3), p = 0.6, respectively), FU1, or FU2. Similarly, no differences were found at FUO, FU1, or FU2 in the subgroups of tumors treated using a single radiofrequency application. The mean volume of the ablation zone decreased over time, by 33.3% at FU1 and 48.5% at FU2, without any difference between groups. Conclusion In contradiction to the "oven effect" theory, RFA achieves ablation zones of a comparable size and volume in cirrhotic and healthy livers.
引用
收藏
页码:905 / 911
页数:7
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