Aging-suppressor Klotho: Prospects in diagnostics and therapeutics

被引：89

作者：

Abraham, Carmela R. ^{[1
,2
,4
]}

Li, Anne ^{[3
,5
]}

机构：

[1] Boston Univ, Sch Med, Dept Biochem, Boston, MA USA

[2] Boston Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA USA

[3] Boston Univ, Sch Med, Div Grad Med Sci, Boston, MA USA

[4] Boston Univ, Sch Med, Dept Biochem, 72 East Concord St, Boston, MA 02118 USA

[5] Boston Univ, Sch Med, Div Grad Med Sci, 72 East Concord St, Boston, MA USA

来源：

AGEING RESEARCH REVIEWS | 2022年 / 82卷

关键词：

Lifespan; Health span; Biomarker; Therapy; Serum; Cerebrospinal fluid; ANTIAGING PROTEIN KLOTHO; FIBROBLAST GROWTH FACTOR-23; SOLUBLE ALPHA-KLOTHO; TRANSCRIPTS ENCODING MEMBRANE; CHRONIC KIDNEY-DISEASE; CEREBROSPINAL-FLUID; TUMOR-SUPPRESSOR; REDUCED KLOTHO; SERUM KLOTHO; CANCER-RISK;

D O I：

10.1016/j.arr.2022.101766

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Introduction: The protein Klotho (KL) was first discovered in KL-deficient mice, which developed a syndrome similar to premature aging in humans. Since then, KL has been implicated in multiple molecular signaling pathways and diseases. KL has been shown to have anti-aging, healthspan and lifespan extending, cognitive enhancing, anti-oxidative, anti-inflammatory, and anti-tumor properties. KL levels decrease with age and in many diseases. Therefore, it has been of great interest to develop a KL-boosting or restoring drug, or to sup-plement endogenous Klotho with exogenous Klotho genetic material or recombinant Klotho protein, and to use KL levels in the body as a marker for the efficacy of such drugs and as a biomarker for the diagnosis and management of diseases.

引用

页数：21

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