Epigenetics in Gastrointestinal Stromal Tumors: Clinical Implications and Potential Therapeutic Perspectives

被引:8
|
作者
Sioulas, Athanasios D. [1 ,2 ]
Vasilatou, Diamantina [1 ,2 ]
Pappa, Vasiliki [1 ,2 ]
Dimitriadis, George [1 ,2 ]
Triantafyllou, Konstantinos [1 ,2 ]
机构
[1] Univ Athens, Sch Med, Attikon Univ Gen Hosp, Dept Internal Med 2, Haidari 12462, Greece
[2] Univ Athens, Sch Med, Attikon Univ Gen Hosp, Res Unit, Haidari 12462, Greece
关键词
GIST; Epigenetics; DNA methylation; Histones; microRNA; DOWN-REGULATION; C-KIT; GENE; EXPRESSION; MUTATIONS; CANCER; CELLS; OVEREXPRESSION; PROGRESSION; MALIGNANCY;
D O I
10.1007/s10620-013-2785-8
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Gastrointestinal stromal tumors (GIST) represent the most common mesenchymal neoplasms affecting the gastrointestinal tract. Activating mutations in either the KIT or PDGFRa gene are the principal oncogenic triggers with the former accounting for more than 80 % of cases. In the small subset of GIST that are wild type for both the aforementioned changes, other germline or somatic mutations have been identified. GIST exhibit a highly variable clinical behavior and the main prognostic determinants are tumor size, mitotic rate, and location. It is, however, strongly believed that, beyond classic genetics, additional epigenetic phenomena such as DNA hypomethylation and hypermethylation, microRNA alterations, and chromatin modifications underlie GIST tumorigenesis and influence the clinical course and response to standard treatment. This review aims to illuminate current advances in terms of epigenetics in GIST, as well as possible implications in prognosis and therapeutics.
引用
收藏
页码:3094 / 3102
页数:9
相关论文
共 50 条
  • [21] Gastrointestinal stromal tumors: prognostic factors and therapeutic implications (vol 98, pg 351, 2012)
    Rosa, Fausto
    Alfieri, Sergio
    Tortorelli, Antonio Pio
    Di Miceli, Dario
    Papa, Valerio
    Ricci, Riccardo
    Doglietto, Giovanni Battista
    TUMORI, 2012, 98 (06) : 812 - 812
  • [22] Gastrointestinal stromal tumors : clinical features and diagnosis
    Landi, Bruno
    BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE, 2012, 196 (4-5): : 845 - 853
  • [23] Clinical characteristics of gastrointestinal stromal tumors with hypoglycemia
    Chida, Akihiko
    Kawasaki, Kenta
    Kuramoto, Junko
    Hayashi, Hideyuki
    Kawahara, Toru
    Makiuchi, Satomi
    So, Eiichiro
    Shimizu, Satoko
    Kishimoto, Shotaro
    Horie, Sara
    Saito, Yuki
    Shimozaki, Keitaro
    Tsugaru, Kai
    Togasaki, Kazuhiro
    Hirata, Kenro
    Nishihara, Hiroshi
    Kanai, Yae
    Kanai, Takanori
    Hamamoto, Yasuo
    ONCOLOGY LETTERS, 2024, 28 (06)
  • [24] A clinical and biological overview of gastrointestinal stromal tumors
    Candelaria, M
    de la Garza, J
    Duenas-Gonzalez, A
    MEDICAL ONCOLOGY, 2005, 22 (01) : 1 - 10
  • [25] Gastrointestinal stromal tumors (GIST):: clinical aspects
    Fernandez Salazar, L. I.
    Alvarez Gago, T.
    Sanz Rubiales, A.
    Velayos Jimenez, B.
    Aller de la Fuente, R.
    Gonzalez Hernandez, J. M.
    REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS, 2007, 99 (01) : 19 - 24
  • [26] A clinical and biological overview of gastrointestinal stromal tumors
    Myrna Candelaria
    Jaime de la Garza
    Alfonso Duenas-Gonzalez
    Medical Oncology, 2005, 22 : 1 - 10
  • [27] Randomized Clinical Trials in Gastrointestinal stromal Tumors
    Liu, Yang
    von Mehren, Margaret
    SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 2017, 26 (04) : 545 - +
  • [28] Randomized Clinical Trials in Gastrointestinal Stromal Tumors
    Learn, Peter A.
    Sicklick, Jason K.
    DeMatteo, Ronald P.
    SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 2010, 19 (01) : 101 - +
  • [29] Clinical presentation and treatment of gastrointestinal stromal tumors
    Cipolla, Calogero
    Fulfaro, Fabio
    Sandonato, Luigi
    Fricano, Salvatore
    Pantuso, Gianni
    Grassi, Nello
    Vieni, Salvatore
    Valerio, Maria Rosaria
    Lo Dico, Rea
    Gebbia, Nicola
    Latteri, Mario Adelfio
    TUMORI, 2006, 92 (04) : 279 - 284
  • [30] VEGF-A Gene and protein status in gastrointestinal stromal tumors - clinical and biological implications
    Salto-Tellez, Manuel
    Min En Nga
    Han, Hwan Chour
    Wong, Alvin
    Lee, Chee Kuen
    Ho, Mien
    Wee, Aileen
    Ng, Swee Siang
    Soong, Richie
    CANCER RESEARCH, 2006, 66 (08)