Age is just a number, the wrong number

被引:1
作者
Bal, Susan [1 ]
Costa, Luciano J. [1 ]
机构
[1] Univ Alabama Birmingham, Dept Med, Div Hematol & Oncol, Birmingham, AL 35294 USA
关键词
age; autologous hematopoietic cell transplantation; frailty; multiple myeloma; toxicity; STEM-CELL TRANSPLANTATION; MULTIPLE-MYELOMA; DOSE MELPHALAN; SURVIVAL; OUTCOMES; DISEASE;
D O I
10.1002/cncr.33170
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Despite the evolution of the therapeutic landscape of multiple myeloma, autologous hematopoietic stem cell transplantation continues to be complementary to novel agents, even among older patients. In this issue ofCancer, Munshi et al report the largest study supporting the role of autologous hematopoietic stem cell transplantation as an effective consolidation strategy across all age groups. The future incorporation of individualized, response- and frailty-adapted treatment paradigms will define the future of myeloma therapy for older adults.
引用
收藏
页码:5014 / 5016
页数:3
相关论文
共 16 条
[1]   Autologous stem cell transplantation in elderly multiple myeloma patients over the age of 70 years [J].
Badros, A ;
Barlogie, B ;
Siegel, E ;
Morris, C ;
Desikan, R ;
Zangari, M ;
Fassas, A ;
Anaissie, E ;
Munshi, N ;
Tricot, G .
BRITISH JOURNAL OF HAEMATOLOGY, 2001, 114 (03) :600-607
[2]   Associations of High-Dose Melphalan Pharmacokinetics and Outcomes in the Setting of a Randomized Cryotherapy Trial [J].
Cho, Y. K. ;
Sborov, D. W. ;
Lamprecht, M. ;
Li, J. ;
Wang, J. ;
Hade, E. M. ;
Gao, Y. ;
Tackett, K. ;
Williams, N. ;
Benson, D. M. ;
Efebera, Y. A. ;
Rosko, A. E. ;
Devine, S. M. ;
Poi, M. ;
Hofmeister, C. C. ;
Phelps, M. A. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2017, 102 (03) :511-519
[3]   Disparities in Utilization of Autologous Hematopoietic Cell Transplantation for Treatment of Multiple Myeloma [J].
Costa, Luciano J. ;
Huang, Jia-Xing ;
Hari, Parameswaran N. .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2015, 21 (04) :701-706
[4]   Trends in Utilization and Outcomes of Autologous Transplantation as Early Therapy for Multiple Myeloma [J].
Costa, Luciano J. ;
Zhang, Mei-Jie ;
Zhong, Xiaobo ;
Dispenzieri, Angela ;
Lonial, Sagar ;
Krishnan, Amrita ;
Freytes, Cesar ;
Vesole, David ;
Gale, Robert Peter ;
Anderson, Kenneth ;
Wirk, Baldeep ;
Savani, Bipin N. ;
Waller, Edmund K. ;
Schouten, Harry ;
Lazarus, Hillard ;
Meehan, Kenneth ;
Sharma, Manish ;
Kamble, Rammurti ;
Vij, Ravi ;
Kumar, Shaji ;
Nishihori, Taiga ;
Kindwall-Keller, Tamila ;
Saber, Wael ;
Hari, Parameswaran N. .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2013, 19 (11) :1615-1624
[5]   Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial [J].
Facon, Thierry ;
Mary, Jean Yves ;
Hulin, Cyrille ;
Benbouker, Lofti ;
Attal, Michel ;
Pegourie, Brigitte ;
Renaud, Marc ;
Guillerm, Jean Luc Harousseau Gaelle ;
Ahletaix, Carine ;
Dib, Mamoun ;
Voillat, Laurent ;
Maisonneuve, Herve ;
Troncy, Jacques ;
Dervaux, Weronique ;
Monconduit, Mathieu ;
Martin, Claude ;
Casassus, Philippe ;
Jaubert, Jerome ;
Jardel, Henry ;
Doyen, Chantal ;
Kolb, Brigitte ;
Anglaret, Bruno ;
Grosbois, Bernard ;
Yakoub-Agha, Ibrahim ;
Mathiot, Claire ;
Avet-Loiseau, Herve .
LANCET, 2007, 370 (9594) :1209-1218
[6]   Autologous stem cell transplantation in patients of 70 years and older with multiple myeloma: Results from a matched pair analysis [J].
Kumar, Shaji K. ;
Dingli, David ;
Lacy, Martha Q. ;
Dispenzieri, Angela ;
Hayman, Suzanne R. ;
Buadi, Francis K. ;
Rajkumar, S. Vincent ;
Litzow, Mark R. ;
Gertz, Morie A. .
AMERICAN JOURNAL OF HEMATOLOGY, 2008, 83 (08) :614-617
[7]   Bortezomib-based induction, high-dose melphalan and lenalidomide maintenance in myeloma up to 70 years of age [J].
Mai, Elias K. ;
Miah, Kaya ;
Bertsch, Uta ;
Duerig, Jan ;
Scheid, Christof ;
Weisel, Katja C. ;
Kunz, Christina ;
Munder, Markus ;
Lindemann, Hans-Walter ;
Merz, Maximilian ;
Hose, Dirk ;
Jauch, Anna ;
Seckinger, Anja ;
Luntz, Steffen ;
Sauer, Sandra ;
Fuhrmann, Stephan ;
Brossart, Peter ;
Elmaagacli, Ahmet ;
Goerner, Martin ;
Bernhard, Helga ;
Hoffmann, Martin ;
Raab, Marc S. ;
Blau, Igor W. ;
Haenel, Mathias ;
Benner, Axel ;
Salwender, Hans J. ;
Goldschmidt, Hartmut .
LEUKEMIA, 2021, 35 (03) :809-822
[8]   Risk of acute myeloid leukemia and myelodysplastic syndromes after multiple myeloma and its precursor disease (MGUS) [J].
Mailankody, Sham ;
Pfeiffer, Ruth M. ;
Kristinsson, Sigurdur Y. ;
Korde, Neha ;
Bjorkholm, Magnus ;
Goldin, Lynn R. ;
Turesson, Ingemar ;
Landgren, Ola .
BLOOD, 2011, 118 (15) :4086-4092
[9]   Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant [J].
Mouhieddine, Tarek H. ;
Sperling, Adam S. ;
Redd, Robert ;
Park, Jihye ;
Leventhal, Matthew ;
Gibson, Christopher J. ;
Manier, Salomon ;
Nassar, Amin H. ;
Capelletti, Marzia ;
Huynh, Daisy ;
Bustoros, Mark ;
Sklavenitis-Pistofidis, Romanos ;
Tahri, Sabrin ;
Hornburg, Kalvis ;
Dumke, Henry ;
Itani, Muhieddine M. ;
Boehner, Cody J. ;
Liu, Chia-Jen ;
AlDubayan, Saud H. ;
Reardon, Brendan ;
Van Allen, Eliezer M. ;
Keats, Jonathan J. ;
Stewart, Chip ;
Mehr, Shaadi ;
Auclair, Daniel ;
Schlossman, Robert L. ;
Munshi, Nikhil C. ;
Anderson, Kenneth C. ;
Steensma, David P. ;
Laubach, Jacob P. ;
Richardson, Paul G. ;
Ritz, Jerome ;
Ebert, Benjamin L. ;
Soiffer, Robert J. ;
Trippa, Lorenzo ;
Getz, Gad ;
Neuberg, Donna S. ;
Ghobrial, Irene M. .
NATURE COMMUNICATIONS, 2020, 11 (01)
[10]   Association of Minimal Residual Disease With Superior Survival Outcomes in Patients With Multiple Myeloma A Meta-analysis [J].
Munshi, Nikhil C. ;
Avet-Loiseau, Herve ;
Rawstron, Andy C. ;
Owen, Roger G. ;
Child, J. Anthony ;
Thakurta, Anjan ;
Sherrington, Paul ;
Samur, Mehmet Kemal ;
Georgieva, Anna ;
Anderson, Kenneth C. ;
Gregory, Walter M. .
JAMA ONCOLOGY, 2017, 3 (01) :28-35