Transfer RNAs: diversity in form and function

被引：68

作者：

Berg, Matthew D. ^{[1
]}

Brandl, Christopher J. ^{[1
]}

机构：

[1] Univ Western Ontario, Dept Biochem, London, ON N6A 5C1, Canada

来源：

RNA BIOLOGY | 2021年 / 18卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

tRNA; translation; aminoacylation; mistranslation; tRNA fragments; AMINOACYL-TRANSFER-RNA; ELONGATION-FACTOR-TU; ISOLEUCYL-TRANSFER-RNA; SERINE TRANSFER-RNA; CODON-ANTICODON INTERACTION; RIBONUCLEIC-ACID SYNTHESIS; PHENYLALANINE TRANSFER-RNA; TATA-BINDING PROTEIN; PRE-MESSENGER-RNA; N-END RULE;

D O I：

10.1080/15476286.2020.1809197

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA structure and function are central to all studies of biology. Yet the complexities of their properties and cellular roles go beyond the view of tRNAs as static participants in protein synthesis. Detailed analyses through more than 60 years of study have revealed tRNAs to be a fascinatingly diverse group of molecules in form and function, impacting cell biology, physiology, disease and synthetic biology. This review analyzes tRNA structure, biosynthesis and function, and includes topics that demonstrate their diversity and growing importance.

引用

页码：316 / 339

页数：24

共 477 条

[1] tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans [J].

Aeby, Eric ;

Ullu, Elisabetta ;

Yepiskoposyan, Hasmik ;

Schimanski, Bernd ;

Roditi, Isabel ;

Muehlemann, Oliver ;

Schneider, Andre .

NUCLEIC ACIDS RESEARCH, 2010, 38 (17) :5833-5843

[2] Structural Insights into tRNA Dynamics on the Ribosome [J].

Agirrezabala, Xabier ;

Valle, Mikel .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 16 (05) :9866-9895

[3] Celebrating wobble decoding: Half a century and still much is new [J].

Agris, Paul F. ;

Eruysal, Emily R. ;

Narendran, Amithi ;

Vaere, Ville Y. P. ;

Vangaveti, Sweta ;

Ranganathan, Srivathsan V. .

RNA BIOLOGY, 2018, 15 (4-5) :537-553

[4] THIOLATION OF URIDINE CARBON-2 RESTRICTS THE MOTIONAL DYNAMICS OF THE TRANSFER-RNA WOBBLE POSITION NUCLEOSIDE [J].

AGRIS, PF ;

SIERZPUTOWSKAGRACZ, H ;

SMITH, W ;

MALKIEWICZ, A ;

SOCHACKA, E ;

NAWROT, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (07) :2652-2656

[5] EFFECT OF GROWTH TEMPERATURES ON IN-VIVO RIBOSE METHYLATION OF BACILLUS-STEAROTHERMOPHILUS TRANSFER-RNA [J].

AGRIS, PF ;

KOH, H ;

SOLL, D .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1973, 154 (01) :277-282

[6] Trans-editing of mischarged tRNAs [J].

Ahel, I ;

Korencic, D ;

Ibba, M ;

Söll, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) :15422-15427

[7] Rapid tRNA decay can result from lack of nonessential modifications [J].

Alexandrov, A ;

Chernyakov, I ;

Gu, WF ;

Hiley, SL ;

Hughes, TR ;

Grayhack, EJ ;

Phizicky, EM .

MOLECULAR CELL, 2006, 21 (01) :87-96

[8] Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA [J].

Alexandrov, A ;

Martzen, MR ;

Phizicky, EM .

RNA, 2002, 8 (10) :1253-1266

[9] C to U editing of the anticodon of imported mitochondrial tRNATrp allows decoding of the UGA stop codon in Leishmania tarentolae [J].

Alfonzo, JD ;

Blanc, V ;

Estévez, AM ;

Rubio, MAT ;

Simpson, L .

EMBO JOURNAL, 1999, 18 (24) :7056-7062

[10] A view of RNase P [J].

Altman, Sidney .

MOLECULAR BIOSYSTEMS, 2007, 3 (09) :604-607

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