Non-coding RNA and immune-checkpoint inhibitors: friends or foes?

被引：19

作者：

Shek, Dmitrii ^{[1
,2
]}

Read, Scott A. ^{[1
,3
,7
]}

Akhuba, Liia ^{[2
]}

Qiao, Liang ^{[3
,4
,5
]}

Gao, Bo ^{[4
,5
,7
]}

Nagrial, Adnan ^{[4
,5
,7
]}

Carlino, Matteo S. ^{[4
,5
,6
,7
]}

Ahlenstiel, Golo ^{[1
,3
,7
]}

机构：

[1] Western Sydney Univ, Blacktown Clin Sch & Res Ctr, Sydney, NSW, Australia

[2] RUDN Univ, Accreditat Ctr, Moscow, Russia

[3] Univ Sydney, Storr Liver Ctr, Westmead Inst Med Res, Sydney, NSW, Australia

[4] Univ Sydney, Westmead Hosp, Sydney, NSW, Australia

[5] Univ Sydney, Westmead Clin Sch, Sydney, NSW, Australia

[6] Melanoma Inst Australia, Sydney, NSW, Australia

[7] Blacktown Hosp, Sydney, NSW, Australia

来源：

IMMUNOTHERAPY | 2020年 / 12卷 / 07期

关键词：

anticancer monoclonal antibodies; cancer immunotherapy; CTLA-4; immune-checkpoint inhibitors; immune checkpoints; long non-coding RNA; microRNA; non-coding RNA; PD-1; PD-L1; CELL LUNG-CANCER; BODY-MASS INDEX; PTEN EXPRESSION; MUSCLE DIFFERENTIATION; 1ST-LINE TREATMENT; BREAST-CANCER; CTLA-4; PROLIFERATION; RESISTANCE; PD-1;

D O I：

10.2217/imt-2019-0204

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Non-coding RNAs (ncRNAs) are an abundant component of the human transcriptome. Their biological role, however, remains incompletely understood. Nevertheless, ncRNAs are highly associated with cancer development and progression due to their ability to modulate gene expression, protein translation and growth pathways. Immune-checkpoint inhibitors (ICIs) are considered one of the most promising and highly effective therapeutic approaches for cancer treatment. ICIs are monoclonal antibodies targeting immune checkpoints such as CTLA-4, PD-1 and PD-L1 signalling pathways that stimulate T cell cytotoxicity and can result in tumor growth suppression. This Review will summarize existing knowledge regarding ncRNAs and their role in cancer and ICI therapy. In addition, we will discuss potential mechanisms by which ncRNAs may influence ICI treatment outcomes.

引用

页码：513 / 530

页数：18

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