Collagen-like Cell-Penetrating Peptides

被引：37

作者：

Yamazaki, Chisato M. ^{[1
]}

Nakase, Ikuhiko ^{[2
]}

Endo, Hiroyuki ^{[1
]}

Kishimoto, Saya ^{[1
]}

Mashiyama, Yoshihiro ^{[1
]}

Masuda, Ryo ^{[1
]}

Futaki, Shiroh ^{[2
]}

Koide, Takaki ^{[1
]}

机构：

[1] Waseda Univ, Dept Chem & Biochem, Sch Adv Sci & Engn, Shinjuku Ku, Tokyo 1698555, Japan

[2] Kyoto Univ, Inst Chem Res, Uji, Kyoto 6110011, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 21期

基金：

日本学术振兴会;

关键词：

cell-penetrating peptides; cellular uptake; collagen; peptides; protein transduction; ARGININE-RICH PEPTIDES; MOLECULAR-STRUCTURE; DESIGN; TRANSPORTERS; DELIVERY; VECTORS; PROTEIN; ENTRY;

D O I：

10.1002/anie.201301266

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Arginine-rich heterotrimeric collagen-like peptides were prepared, and their cellular uptake efficiency was evaluated. The spatial arrangement of the Arg residues (blue in picture) on the triple-helix surface significantly affected the efficacy of the cellular uptake. The collagen-like triple-helical conformation provides these cell-penetrating peptides with a high resistance to proteases. O=L-4-hydroxyproline. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5497 / 5500

页数：4

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