Probiotic Bacteria Induce a 'Glow of Health'

被引：132

作者：

Levkovich, Tatiana ^{[1
]}

Poutahidis, Theofilos ^{[1
,2
]}

Smillie, Christopher

Varian, Bernard J. ^{[1
]}

Ibrahim, Yassin M. ^{[1
]}

Lakritz, Jessica R. ^{[1
]}

Alm, Eric J. ^{[1
,3
]}

Erdman, Susan E. ^{[1
]}

机构：

[1] MIT, Div Comparat Med, Cambridge, MA 02139 USA

[2] Aristotle Univ Thessaloniki, Pathol Lab, Fac Vet Med, GR-54006 Thessaloniki, Greece

[3] Broad Inst MIT & Harvard, Cambridge, MA USA

来源：

PLOS ONE | 2013年 / 8卷 / 01期

基金：

美国国家卫生研究院;

关键词：

GUT MICROBIOTA; IMMUNE-SYSTEM; SKIN INFLAMMATION; HAIR-FOLLICLES; PATHOGENESIS; RESPONSES; RECEPTOR; MODELS; IL-10; CELLS;

D O I：

10.1371/journal.pone.0053867

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Radiant skin and hair are universally recognized as indications of good health. However, this 'glow of health' display remains poorly understood. We found that feeding of probiotic bacteria to aged mice induced integumentary changes mimicking peak health and reproductive fitness characteristic of much younger animals. Eating probiotic yogurt triggered epithelial follicular anagen-phase shift with sebocytogenesis resulting in thick lustrous fur due to a bacteria-triggered interleukin-10-dependent mechanism. Aged male animals eating probiotics exhibited increased subcuticular folliculogenesis, when compared with matched controls, yielding luxuriant fur only in probiotic-fed subjects. Female animals displayed probiotic-induced hyperacidity coinciding with shinier hair, a feature that also aligns with fertility in human females. Together these data provide insights into mammalian evolution and novel strategies for integumentary health.

引用

页数：11

共 47 条

[1] Centrally administered oxytocin elicits exaggerated grooming in oxytocin null mice [J].