Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg.

被引：13

作者：

de Azevedo, Maycow Marcos L. ^{[1
]}

Cascaes, Marcia M. ^{[2
]}

Guilhon, Giselle Maria S. P. ^{[1
]}

Andrade, Eloisa Helena A. ^{[1
,3
]}

Zoghbi, Maria das Gracas B. ^{[3
]}

da Silva, Joyce Kelly R. ^{[4
]}

Santos, Lourivaldo S. ^{[1
]}

da Silva, Silvia Helena M. ^{[5
]}

机构：

[1] Univ Fed Para, Inst Ciencias Exatas & Nat, Programa Posgrad Quim, Belem, Para, Brazil

[2] Museu Paraense Emilio Goeldi, Coordenacao Bot, Programa Capacitacao Inst, Belem, Para, Brazil

[3] Museu Paraense Emilio Goeldi, Belem, Para, Brazil

[4] Univ Fed Para, Programa Posgrad Biotecnol, Belem, Para, Brazil

[5] Inst Evandro Chagas, Secao Bacteriol & Micol SABMI, Lab Micol, Ananindeua, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 04期

关键词：

Myrciaria floribunda; 2; alpha; 6; 30-trihydroxybetulinic acid; DPPH; antibacterial activity; betulinic acid; ESSENTIAL OILS; LEAVES; FRUIT; CONSTITUENTS; ACID;

D O I：

10.1080/14786419.2017.1402311

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chemical composition of the methanol extract of Myrciaria floribunda leaves was investigated. The nor-lupane triterpenoids platanic acid and messagenic I acid were identified, along with other known triterpenoids (betulinic aldehyde, ursolic acid acetate and betulinic acid), a new lupane triterpenoid (2 alpha,6 alpha,30-trihydroxybetulinic acid) and the flavonoids catechin, quercetrin and mirycitrin. The structures were determined by spectroscopic methods (NMR, LC-MS, GC-MS). The major isolated compound was betulinic acid. The methanol extract and 2 alpha,6 alpha,30-trihydroxybetulinic acid were evaluated for their DPPH scavenging potential. The tested triterpenoid was one hundred times more active than betulinic acid, but less active than the extract. Screening for antimicrobial activity showed that the methanol extract was active against Staphylococcus aureus and Escherichia coli, but inactive against Candida albicans and Candida krusei, while 2 alpha,6 alpha,30-trihydroxybetulinic acid was inactive to all tested microorganisms. [GRAPHICS] .

引用

页码：506 / 515

页数：10

共 36 条

[1]

Adesanwo J. K., 2013, Journal of Pharmacy Research, V6, P903, DOI 10.1016/j.jopr.2013.09.003

[2]

Ahmad ViqarUddin., 1994, HDB NATURAL PRODUCTS, V2

[3] Antibacterial constituents of the leaves of Dacryodes edulis [J].

Ajibesin, Kola K. ;

Essien, Etienne E. ;

Adesanya, Saburi A. .

AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2011, 5 (15) :1782-1786

[4]

Apel M.A., 2006, Pharmacologyonline, V3, P376

[5]

Berger S., 2009, CLASSICS SPECTROSCOP, DOI 10.1002/ange.200904430

[6] Active compounds and medicinal properties of Myrciaria genus [J].

Borges, Leonardo Luiz ;

Conceicao, Edemilson Cardoso ;

Silveira, Damaris .

FOOD CHEMISTRY, 2014, 153 :224-233

[7]

Bose Sankhadip., 2013, Journal of Pharma Sci Tech, V2, P72

[8]

BRAND-WILLIAMS W, 1995, FOOD SCI TECHNOL-LEB, V28, P25

[9]

Cerkus M, 2007, QUIM NOVA, V3, P597, DOI [10.1590/S0100-40422007000300018, DOI 10.1590/S0100-40422007000300018]

[10]

Chanda S, 2010, AFR J BIOTECHNOL, V9, P3210

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