Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies

被引：127

作者：

Gelfo, Valerio ^{[1
,2
]}

Romaniello, Donatella ^{[1
,2
]}

Mazzeschi, Martina ^{[1
]}

Sgarzi, Michela ^{[1
]}

Grilli, Giada ^{[1
]}

Morselli, Alessandra ^{[1
]}

Manzan, Beatrice ^{[1
]}

Rihawi, Karim ^{[3
]}

Lauriola, Mattia ^{[1
,2
]}

机构：

[1] Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, I-40138 Bologna, Italy

[2] Bologna Univ Hosp Author, St Orsola Malpighi Polyclin, Ctr Appl Biomed Res CRBA, I-40138 Bologna, Italy

[3] Univ Bologna, Dept Oncol, Policlin S Orsola Malpighi, I-40138 Bologna, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 17期

关键词：

IL-1; cancer; resistance; COLORECTAL-CANCER; SUPPRESSOR-CELLS; T-CELLS; IN-VIVO; KAPPA-B; INFLAMMATION; INTERLEUKIN-1; PROMOTES; IL-1-ALPHA; INVASIVENESS;

D O I：

10.3390/ijms21176009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-inflammatory activity. Beyond its biological role as a regulator of the innate immune response, IL-1 is involved in stress and chronic inflammation, therefore it is responsible for several pathological conditions. In particular, IL-1 is known to exert a critical function in malignancies, influencing the tumor microenvironment and promoting cancer initiation and progression. Thus, it orchestrates immunosuppression recruiting pro-tumor immune cells of myeloid origin. Furthermore, new recent findings showed that this cytokine can be directly produced by tumor cells in a positive feedback loop and contributes to the failure of targeted therapy. Activation of anti-apoptotic signaling pathways and senescence are some of the mechanisms recently proposed, but the role of IL-1 in tumor cells refractory to standard therapies needs to be further investigated.

引用

页码：1 / 14

页数：14

共 91 条

[1] The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer [J].