Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism

被引：84

作者：

Al-Farsi, Yahya M. ^{[1
]}

Waly, Mostafa I. ^{[2
,7
]}

Deth, Richard C. ^{[3
]}

Al-Sharbati, Marwan M. ^{[4
]}

Al-Shafaee, Mohamed ^{[1
]}

Al-Farsi, Omar ^{[1
]}

Al-Khaduri, Maha M. ^{[5
]}

Gupta, Ishita ^{[6
]}

Ali, Amanat ^{[2
]}

Al-Khalili, Maha ^{[1
]}

Al-Adawi, Samir ^{[4
]}

Hodgson, Nathaniel W. ^{[3
]}

Ouhtit, Allal ^{[6
]}

机构：

[1] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Family Med & Publ Hlth, Muscat, Oman

[2] Sultan Qaboos Univ, Coll Agr & Marine Sci, Dept Food Sci & Nutr, Muscat, Oman

[3] Northeastern Univ, Dept Pharmaceut Sci, Boston, MA 02115 USA

[4] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Behav Med, Muscat, Oman

[5] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Obstet & Gynecol, Muscat, Oman

[6] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Genet, Muscat, Oman

[7] Univ Alexandria, High Inst Publ Hlth, Dept Nutr, Alexandria, Egypt

来源：

NUTRITION | 2013年 / 29卷 / 03期

关键词：

Autism; Folate; Methylation; Nutrition; Oman; Vitamin B12; FOLIC-ACID FORTIFICATION; YOUNG-CHILDREN; DEFICIENCY; DISORDER; MALNUTRITION; HYPERHOMOCYSTEINEMIA; IDENTIFICATION; MANAGEMENT; INFANTS; ANEMIA;

D O I：

10.1016/j.nut.2012.09.014

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Objective: Arab populations lack data related to nutritional assessment in children with autism spectrum disorders (ASDs), especially micronutrient deficiencies such as folate and vitamin B12. Methods: To assess the dietary and serum folate and vitamin B12 statuses, a hospital-based case-control study was conducted in 80 Omani children (40 children with ASDs versus 40 controls). Results: The ASD cases showed significantly lower levels of folate, vitamin B12, and related parameters in dietary intake and serum levels. Conclusion: These data showed that Omani children with ASDs exhibit significant deficiencies in folate and vitamin B12 and call for increasing efforts to ensure sufficient intakes of essential nutrients by children with ASDs to minimize or reverse any ongoing impact of nutrient deficiencies. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：537 / 541

页数：5

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