Complex Small-Molecule Architectures Regulate Phenotypic Plasticity in a Nematode

被引：90
作者：
Bose, Neelanjan [2 ,3 ,4 ]
Ogawa, Akira [1 ]
von Reuss, Stephan H. [2 ,3 ,4 ]
Yim, Joshua J. [2 ,3 ,4 ]
Ragsdale, Erik J. [1 ]
Sommer, Ralf J. [1 ]
Schroeder, Frank C. [2 ,3 ,4 ]
机构：
[1] Max Planck Inst Dev Biol, Dept Evolutionary Biol, Tubingen, Germany
[2] Cornell Univ, Boyce Thompson Inst, Ithaca, NY USA
[3] Cornell Univ, Dept Chem, Ithaca, NY 14853 USA
[4] Cornell Univ, Dept Biol Chem, Ithaca, NY USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 50期
基金：
美国国家卫生研究院;
关键词：
metabolomics; model organisms; natural products; pheromones; small-molecule signaling; PRISTIONCHUS-PACIFICUS; CAENORHABDITIS-ELEGANS; METABOLOMICS REVEALS; BIOSYNTHESIS; PHEROMONE; ASCAROSIDES; METABOLITES; SIGNALS;
D O I：
10.1002/anie.201206797
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Chemistry the worm's way: The nematode Pristionchus pacificus constructs elaborate small molecules from modified building blocks of primary metabolism, including an unusual xylopyranose-based nucleoside (see scheme). These compounds act as signaling molecules to control adult phenotypic plasticity and dauer development and provide examples of modular generation of structural diversity in metazoans. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：12438 / 12443
页数：6
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