Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus

被引：201

作者：

Nuebel, Ulrich ^{[1
]}

Roumagnac, Philippe ^{[2
]}

Feldkamp, Mirjam ^{[2
]}

Song, Jae-Hoon ^{[3
]}

Ko, Kwan Soo ^{[4
]}

Huang, Yhu-Chering ^{[5
]}

Coombs, Geoffrey ^{[6
]}

Ip, Margaret ^{[7
]}

Westh, Henrik ^{[8
,9
]}

Skov, Robert ^{[9
]}

Struelens, Marc J. ^{[10
]}

Goering, Richard V. ^{[11
]}

Strommenger, Birgit ^{[1
]}

Weller, Annette ^{[1
]}

Witte, Wolfgang ^{[1
]}

Achtman, Mark ^{[2
,12
]}

机构：

[1] Robert Koch Inst, D-38855 Wernigerode, Germany

[2] Max Planck Inst Infekt Biol, D-10117 Berlin, Germany

[3] Samsung Med Ctr, Seoul 135710, South Korea

[4] Sungkyunkwan Univ, Sch Med, Suwon 440746, South Korea

[5] Chang Gung Childrens Hosp, Tao Yuan 333, Taiwan

[6] Royal Perth Hosp, Perth, WA 6847, Australia

[7] Prince Wales Hosp, Shatin, Hong Kong, Peoples R China

[8] Univ Copenhagen, Hvidovre Hosp, DK-2650 Hvidovre, Denmark

[9] Statens Serum Inst, DK-2300 Copenhagen S, Denmark

[10] Univ Libre Bruxelles, Erasme Hosp, Brussels, Belgium

[11] Creighton Univ, Sch Med, Omaha, NE 68178 USA

[12] Natl Univ Ireland Univ Coll Cork, Environm Res Inst, Cork, Ireland

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 37期

关键词：

antibiotic resistance; evolution; phylogeography; SNP;

D O I：

10.1073/pnas.0804178105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A small number of clonal lineages dominates the global population structure of methicillin-resistant Staphylococcus aureus (MRSA), resulting in the concept that MRSA has emerged on a few occasions after penicillinase-stable beta-lactam antibiotics were introduced to clinical practice, followed by intercontinental spread of individual clones. We investigated the evolutionary history of an MRSA clone (ST5) by mutation discovery at 108 loci (46 kb) within a global collection of 135 isolates. The SNPs that were ascertained define a radial phylogenetic structure within ST5 consisting of at least 5 chains of mutational steps that define geographically associated clades. These clades are not concordant with previously described groupings based on staphylococcal protein A gene (spa) typing. By mapping the number of independent imports of the staphylococcal cassette chromosome methicillin-resistance island, we also show that import has occurred on at least 23 occasions within this single sequence type and that the progeny of such recombinant strains usually are distributed locally rather than globally. These results provide strong evidence that geographical spread of MRSA over long distances and across cultural borders is a rare event compared with the frequency with which the staphylococcal cassette chromosome island has been imported.

引用

页码：14130 / 14135

页数：6

共 42 条

[1] Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis [J].