A Review of Acetaminophen Poisoning

被引：218

作者：

Hodgman, Michael J. ^{[1
,2
]}

Garrard, Alexander R. ^{[1
]}

机构：

[1] SUNY Upstate Med Univ, Upstate New York Poison Ctr, Dept Emergency Med, Syracuse, NY 13202 USA

[2] Bassett Med Ctr, Emergency & Trauma Serv, Cooperstown, NY 13326 USA

来源：

CRITICAL CARE CLINICS | 2012年 / 28卷 / 04期

关键词：

Acetaminophen poisoning; Acetaminophen overdose; N-acetylcysteine; Hepatotoxicity; Fulminant hepatic failure; Liver transplant; Paracetamol; ACUTE LIVER-FAILURE; INTRAVENOUS N-ACETYLCYSTEINE; FULMINANT HEPATIC-FAILURE; EARLY METABOLIC-ACIDOSIS; TYLENOL EXTENDED RELIEF; PARACETAMOL ACETAMINOPHEN; ACTIVATED-CHARCOAL; SERUM PHOSPHATE; MITOCHONDRIAL GLUTATHIONE; ANAPHYLACTOID REACTIONS;

D O I：

10.1016/j.ccc.2012.07.006

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Acetaminophen poisoning remains one of the more common drugs taken in overdose with potentially fatal consequences. Early recognition and prompt treatment with N-acetylcysteine can prevent hepatic injury. With acute overdose, the Rumack-Matthew nomogram is a useful tool to assess risk and guide management. Equally common to acute overdose is the repeated use of excessive amounts of acetaminophen. Simultaneous ingestion of several different acetaminophen-containing products may result in excessive dosage. These patients also benefit from N-acetylcysteine. Standard courses of N-acetylcysteine may need to be extended in patients with persistently elevated plasma concentrations of acetaminophen or with signs of hepatic injury.

引用

页码：499 / +

页数：19

共 116 条

[21] 2009 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 27th Annual Report [J].

Bronstein, Alvin C. ;

Spyker, Daniel A. ;

Cantilena, Louis R., Jr. ;

Green, Jody L. ;

Rumack, Barry H. ;

Giffin, Sandra L. .

CLINICAL TOXICOLOGY, 2010, 48 (10) :979-1178

[22] Oral or intravenous N-acetylcysteine:: Which is the treatment of choice for acetaminophen (paracetamol) poisoning? [J].

Buckley, NA ;

Whyte, IM ;

O'Connell, DL ;

Dawson, AH .

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 1999, 37 (06) :759-767

[23]

Caravati EM, 2000, J TOXICOL-CLIN TOXIC, V38, P291

[24] Tylenol extended relief overdose [J].

Cetaruk, EW ;

Dart, RC ;

Hurlbut, KM ;

Horowitz, RS ;

Shih, R .

ANNALS OF EMERGENCY MEDICINE, 1997, 30 (01) :104-108

[25] Activated charcoal alone or after gastric lavage: a simulated large paracetamol intoxication [J].

Christophersen, AB ;

Levin, D ;

Hoegberg, LCG ;

Angelo, HR ;

Kampmann, JP .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2002, 53 (03) :312-317

[26] Paracetamol (acetaminophen) attenuates in vitro mast cell and peripheral blood mononucleocyte cell histamine release induced by N-acetylcysteine [J].

Coulson, James ;

Thompson, John Paul .

CLINICAL TOXICOLOGY, 2010, 48 (02) :111-114

[27] N-ACETYL-PARA-BENZOQUINONE IMINE - A CYTOCHROME-P-450-MEDIATED OXIDATION-PRODUCT OF ACETAMINOPHEN [J].

DAHLIN, DC ;

MIWA, GT ;

LU, AYH ;

NELSON, SD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05) :1327-1331

[28] Prospective evaluation of repeated supratherapeutic acetaminophen (Paracetamol) ingestion [J].

Daly, FFS ;

O'Malley, GF ;

Heard, K ;

Bogdan, GM ;

Dart, RC .

ANNALS OF EMERGENCY MEDICINE, 2004, 44 (04) :393-398

[29] Measuring plasma paracetamol concentrations in all patients with drug overdose or altered consciousness: Does it change outcome? [J].

Dargan, PI ;

Ladhani, S ;

Jones, AL .

EMERGENCY MEDICINE JOURNAL, 2001, 18 (03) :178-182

[30] The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study [J].

Dart, R. C. ;

Green, J. L. ;

Kuffner, E. K. ;

Heard, K. ;

Sproule, B. ;

Brands, B. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2010, 32 (03) :478-486

← 1 2 3 4 5 6 7 8 9 10 →