A Review of Acetaminophen Poisoning

被引：218

作者：

Hodgman, Michael J. ^{[1
,2
]}

Garrard, Alexander R. ^{[1
]}

机构：

[1] SUNY Upstate Med Univ, Upstate New York Poison Ctr, Dept Emergency Med, Syracuse, NY 13202 USA

[2] Bassett Med Ctr, Emergency & Trauma Serv, Cooperstown, NY 13326 USA

来源：

CRITICAL CARE CLINICS | 2012年 / 28卷 / 04期

关键词：

Acetaminophen poisoning; Acetaminophen overdose; N-acetylcysteine; Hepatotoxicity; Fulminant hepatic failure; Liver transplant; Paracetamol; ACUTE LIVER-FAILURE; INTRAVENOUS N-ACETYLCYSTEINE; FULMINANT HEPATIC-FAILURE; EARLY METABOLIC-ACIDOSIS; TYLENOL EXTENDED RELIEF; PARACETAMOL ACETAMINOPHEN; ACTIVATED-CHARCOAL; SERUM PHOSPHATE; MITOCHONDRIAL GLUTATHIONE; ANAPHYLACTOID REACTIONS;

D O I：

10.1016/j.ccc.2012.07.006

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Acetaminophen poisoning remains one of the more common drugs taken in overdose with potentially fatal consequences. Early recognition and prompt treatment with N-acetylcysteine can prevent hepatic injury. With acute overdose, the Rumack-Matthew nomogram is a useful tool to assess risk and guide management. Equally common to acute overdose is the repeated use of excessive amounts of acetaminophen. Simultaneous ingestion of several different acetaminophen-containing products may result in excessive dosage. These patients also benefit from N-acetylcysteine. Standard courses of N-acetylcysteine may need to be extended in patients with persistently elevated plasma concentrations of acetaminophen or with signs of hepatic injury.

引用

页码：499 / +

页数：19

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