The role of thiamine in HIV infection

被引：21

作者：

Khanh vinh quoc Lu'o'ng ^{[1
]}

Lan Thi Hoang Nguyen ^{[1
]}

机构：

[1] Vietnamese Amer Med Res Fdn, Westminster, CA 92683 USA

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2013年 / 17卷 / 04期

关键词：

Thiamine; HIV; Human immunodeficiency virus; Vitamin B1; Transketolase; IMMUNODEFICIENCY-VIRUS TYPE-1; ENDOTHELIAL GROWTH-FACTOR; GLYCOGEN-SYNTHASE KINASE-3-BETA; ANGIOTENSIN-CONVERTING ENZYME; PROTEASE INHIBITOR RITONAVIR; NITRIC-OXIDE SYNTHASE; APOPTOTIC CELL-DEATH; OXIDATIVE STRESS; HEME OXYGENASE-1; POLY(ADP-RIBOSE) POLYMERASE-1;

D O I：

10.1016/j.ijid.2012.11.019

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Patients infected with HIV have a high prevalence of thiamine deficiency. Genetic studies have provided the opportunity to determine which proteins link thiamine to HIV pathology, i.e., renin-angiotensin system, poly(ADP-ribosyl) polymerase 1, Sp1 promoter gene, transcription factor p53, apoptotic factor caspase 3, and glycogen synthetase kinase 3 beta. Thiamine also affects HIV through non-genomic factors, i.e., matrix metalloproteinase, vascular endothelial growth factor, heme oxygenase 1, the prostaglandins, cyclooxygenase 2, reactive oxygen species, and nitric oxide. In conclusion, thiamine may benefit HIV patients, but further investigation of the role of thiamine in HIV infection is needed. (c) 2012 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

引用

页码：E221 / E227

页数：7

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