Rho family proteins: coordinating cell responses

被引：619

作者：

Ridley, AJ

机构：

[1] Royal Free & Univ Coll Med Sch, Sch Med, Ludwig Inst Canc Res, London W1W 7BS, England

[2] UCL, Dept Biochem & Mol Biol, London, England

来源：

TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 12期

关键词：

D O I：

10.1016/S0962-8924(01)02153-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rho GTPases hit the headlines several times in 1990-1992: the proteins regulating their GTP-GDP cycle were identified and they were found to be key signal transducers, mediating growth factor-induced changes to the actin cytoskeleton and activating the phagocyte NADPH oxidase. Since then, they have been implicated in numerous cellular processes, from cell migration to cell survival, transcriptional regulation and vesicle trafficking. An explanation for why they affect so many aspects of cell behavior might lie in their ability to interact with a number of downstream targets, so that they can coordinately activate several molecular processes required for a particular cellular response.

引用

页码：471 / 477

页数：7

共 75 条

[1] Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein [J].