OPA1 in Cardiovascular Health and Disease

被引：18

作者：

Burke, Niall ^{[1
]}

Hall, Andrew R. ^{[1
]}

Hausenloy, Derek J. ^{[1
,2
,3
]}

机构：

[1] UCL, Hatter Cardiovasc Inst, 67 Chenies Mews, London WC1E 6HX, England

[2] Duke NUS Grad Med Sch, Cardiovasc & Metab Disorders Program, Singapore, Singapore

[3] Natl Heart Ctr, Natl Heart Res Inst Singapore, Singapore, Singapore

来源：

CURRENT DRUG TARGETS | 2015年 / 16卷 / 08期

基金：

英国医学研究理事会;

关键词：

Cardiovascular disease; fission; fusion; mitochondrial morphology; OPA1; DOMINANT OPTIC ATROPHY; CYTOCHROME-C RELEASE; MITOCHONDRIAL PROTEASE OMA1; DYNAMIN-RELATED PROTEIN; PROTEOLYTIC CLEAVAGE; OXIDATIVE-PHOSPHORYLATION; RESPIRATORY-CHAIN; GTPASE OPA1; FUSION; MORPHOLOGY;

D O I：

10.2174/1389450116666150102113648

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mitochondria are known to play crucial roles in normal cellular physiology and in more recent years they have been implicated in a wide range of pathologies. Central to both these roles is their ability to alter their shape interchangeably between two different morphologies: an elongated interconnected network and a fragmented discrete phenotype - processes which are under the regulation of the mitochondrial fusion and fission proteins, respectively. In this review article, we focus on the mitochondrial fusion protein optic atrophy protein 1 (OPA1) in cardiovascular health and disease and we explore its role as a potential therapeutic target for treating cardiovascular and metabolic disease.

引用

页码：912 / 920

页数：9

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