Extracorporeal photopheresis for the treatment of autoimmune diseases

被引：22

作者：

Adamski, Jill ^{[1
]}

Kinard, Theresa ^{[1
]}

Ipe, Tina ^{[2
]}

Cooling, Laura ^{[3
]}

机构：

[1] Mayo Clin Arizona, Dept Lab Med & Pathol, Phoenix, AZ 85054 USA

[2] Houston Methodist Hosp, Dept Pathol & Genom Med, Houston, TX USA

[3] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2015年 / 52卷 / 02期

关键词：

Autoimmune; Photopheresis; ECP; REGULATORY T-CELLS; EPIDERMOLYSIS-BULLOSA ACQUISITA; PLACEBO-CONTROLLED TRIAL; EOSINOPHILIC FASCIITIS; PEMPHIGUS-VULGARIS; ATOPIC-DERMATITIS; PSORIATIC-ARTHRITIS; DENDRITIC CELLS; LICHEN-PLANUS; DOUBLE-BLIND;

D O I：

10.1016/j.transci.2015.02.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The immune system is tasked with the unique challenge of recognizing foreign pathogens and damaged cells while at the same time preserving and protecting the integrity of "self". When this process fails, severe consequences including cancer and autoimmunity are the end result. Current therapies aimed at treating autoimmune disorders result in generalized immunosuppression and place the patient at increased risk for infection and malignancy. ECP is a potential therapeutic intervention that recapitulates natural physiologic processes of tolerance induction to restore immune homeostasis. Several clinical trials suggest that ECP may be used to treat a broad spectrum of autoimmune diseases. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：171 / 182

页数：12

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