The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis

被引：608

作者：

Hirayama, Daisuke ^{[1
]}

Iida, Tomoya ^{[1
]}

Nakase, Hiroshi ^{[1
]}

机构：

[1] Sapporo Med Univ, Sch Med, Dept Gastroenterol & Hepatol, Chuo Ku, Minami 1 Jo Nishi 16 Chome, Sapporo, Hokkaido 0608543, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 01期

基金：

日本学术振兴会;

关键词：

macrophages; innate immunity; phagocytosis; TUMOR-ASSOCIATED MACROPHAGES; RECEPTOR-MEDIATED PHAGOCYTOSIS; PATTERN-RECOGNITION RECEPTORS; RED PULP MACROPHAGES; FREE FATTY-ACIDS; SCAVENGER RECEPTOR; KUPFFER CELLS; INSULIN-RESISTANCE; APOPTOTIC CELLS; ADIPOSE-TISSUE;

D O I：

10.3390/ijms19010092

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophages are effector cells of the innate immune system that phagocytose bacteria and secrete both pro-inflammatory and antimicrobial mediators. In addition, macrophages play an important role in eliminating diseased and damaged cells through their programmed cell death. Generally, macrophages ingest and degrade dead cells, debris, tumor cells, and foreign materials. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes, but also through trophic, regulatory, and repair functions. Recent studies demonstrated that macrophages differentiate from hematopoietic stem cell-derived monocytes and embryonic yolk sac macrophages. The latter mainly give rise to tissue macrophages. Macrophages exist in all vertebrate tissues and have dual functions in host protection and tissue injury, which are maintained at a fine balance. Tissue macrophages have heterogeneous phenotypes in different tissue environments. In this review, we focused on the phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis for a better understanding of the role of tissue macrophages in several pathological conditions.

引用

页数：14

共 97 条

[1] Effector molecules in expression of the antimicrobial activity of macrophages against Mycobacterium avium complex: roles of reactive nitrogen intermediates, reactive oxygen intermediates, and free fatty acids [J].