Facile preparation of the N-acetyl-glucosaminylated asparagine derivative with TFA-sensitive protecting groups useful for solid-phase glycopeptide synthesis

被引：3

作者：

Katayama, Hidekazu ^{[1
]}

机构：

[1] Tokai Univ, Dept Appl Biochem, Sch Engn, Hiratsuka, Kanagawa 2591292, Japan

来源：

JOURNAL OF PEPTIDE SCIENCE | 2015年 / 21卷 / 09期

关键词：

N-acetylglucosamine; glycopeptide; insulin-like androgenic gland factor; solid-phase peptide synthesis; CHEMOENZYMATIC SYNTHESIS; ACETYLGLUCOSAMINIDASE; TRANSGLYCOSYLATION; OLIGOSACCHARIDES; GLYCODELIN;

D O I：

10.1002/psc.2792

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, a novel N-acetyl-glucosaminylated asparagine derivative was developed. This derivative carried TFA-sensitive protecting groups and was derived from commercially available compounds only in three steps. It was applicable to the ordinary 9-fluorenylmethoxycarbonyl (Fmoc)-based solid-phase peptide synthesis (SPPS) method, and the protecting groups on the carbohydrate moiety could be removed by a single step of TFA cocktail treatment generally used for the final deprotection step in Fmoc-SPPS. Copyright (c) 2015 European Peptide Society and John Wiley & Sons, Ltd.

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页码：696 / 699

页数：4

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