The plasma membrane redox system in human platelet functions and platelet-leukocyte interactions

被引：16
|
作者：
Del Principe, Domenico [1 ]
Frega, Gianluca [1 ]
Savini, Isabella [2 ]
Catani, M. Valeria [2 ]
Rossi, Antonello [2 ]
Avigliano, Luciana [2 ]
机构：
[1] Univ Roma Tor Vergata, Dept Publ Hlth & Cell Biol, I-00133 Rome, Italy
[2] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy
来源：
THROMBOSIS AND HAEMOSTASIS | 2009年 / 101卷 / 02期
关键词：
Platelets; plasma membrane redox system; NAD(P)H oxidase; ubiquinone; antioxidant vitamins; PROTEIN DISULFIDE-ISOMERASE; NADH OXIDASE ACTIVITY; NAD(P)H OXIDASE; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; ALPHA-TOCOPHEROL; BLOOD-PLATELETS; NITRIC-OXIDE; ELECTRON-TRANSPORT; EXTRACELLULAR RNA;
D O I：
10.1160/TH08-05-0300
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The plasma membrane electron transport is crucial for blood coagulation and thrombosis, since reactive oxygen species and thiol changes, generated by plasma membrane redox reactions, modulate activation of platelets, as well as their interaction with leukocytes. Several antioxidants are linked to this system; thus, platelets are also able to counterbalance radical production and to regulate thrombus growth. Aim of this review is to give an update on the plasma membrane redox system in platelets, as well as on its role in platelet functions and leukocyte-platelet crosstalk.
引用
收藏
页码：284 / 289
页数：6
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