Photo-crosslinked poly(ethylene glycol)-b-poly(ε-caprolactone) nanoparticles for controllable paclitaxel release

被引：3
|
作者：
Chang, Longlong [1 ]
Wang, Weiwei [2 ,3 ]
Huang, Pingsheng [1 ]
Lv, Zesheng [1 ]
Hu, Fuqiang [4 ]
Zhang, Jianhua [1 ]
Kong, Deling [2 ,3 ]
Deng, Liandong [1 ]
Dong, Anjie [1 ,5 ]
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China
[2] Chinese Acad Med Sci, Tianjin 300072, Peoples R China
[3] Peking Union Med Coll, Inst Biomed Engn, Tianjin 300072, Peoples R China
[4] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
[5] Minist Educ China, Key Lab Syst Bioengn, Tianjin 300072, Peoples R China
来源：
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2013年 / 24卷 / 16期
基金：
中国国家自然科学基金;
关键词：
photo-crosslinking; amphiphilic diblock copolymer; nanoparticles; poly(epsilon-caprolactone); cinnamoyloxy groups; drug delivery; BLOCK-COPOLYMER MICELLES; POLYMERIC MICELLES; DRUG; DELIVERY; LINKING; CORES; METHACRYLATE); FLUORESCENCE; CARRIERS;
D O I：
10.1080/09205063.2013.808152
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Novel biodegradable core-crosslinked nanoparticles (CNPs) consisting of methoxy poly(ethylene glycol)-block-poly(E-caprolactone-co--cinnamoyloxy-E-caprolactone) (mPEG-b-P(CL-co-CCL)) were prepared and evaluated for paclitaxel (PTX) delivery. mPEG(113)-b-P(CL65.2-co-CCL10.1) had a higher drug loading efficiency (95%) compared to mPEG(113)-b-PCL93.1 (43%). The stability of NPs has been largely improved and PTX release was significantly inhibited by crosslinking via UV irradiation at =254nm. MTT assays demonstrated that both blank non-crosslinked and crosslinked NPs showed low cytotoxicity to NCL-H460 cells while PTX-loaded non-crosslinked and crosslinked NPs exhibited obvious cytotoxicity against NCL-H460 cells, and the cytotoxicity was both dose-dependent and time-dependent. Furthermore, after 48h incubation the cell viability of PTX-loaded crosslinked NPs was lower compared to that of PTX-loaded non-crosslinked NPs or free PTX. These properties indicated that CNPs prepared from mPEG-b-P(CL-co-CCL) have great potentials as carriers for drug delivery.
引用
收藏
页码：1900 / 1921
页数：22
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