Clinical significance of soluble adhesion molecules in anti-NMDAR encephalitis patients

被引：4

作者：

Ding, Yuewen ^{[1
,2
]}

Yang, Chengjia ^{[3
,4
]}

Zhou, Zheyi ^{[4
,5
]}

Peng, Yu ^{[1
]}

Chen, Jinyu ^{[1
]}

Pan, Suyue ^{[1
]}

Xu, Hong ^{[4
]}

Cai, Yuping ^{[6
]}

Ou, Kaiyun ^{[7
]}

Xie, Wei ^{[2
,8
]}

Wang, Honghao ^{[1
]}

机构：

[1] Southern Med Univ, Dept Neurol, Nanfang Hosp, 1838 North Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China

[2] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China

[3] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Mental Hlth Ctr, Guangzhou, Guangdong, Peoples R China

[4] Southern Med Univ, Sch Clin Med 2, Guangzhou, Guangdong, Peoples R China

[5] Liuzhou Tradit Chinese Med Hosp, Dept Neurol, Liuzhou, Peoples R China

[6] Hexian Mem Hosp, Guangzhou, Guangdong, Peoples R China

[7] Laibin Peoples Hosp, Dept Neurol, Laibin, Peoples R China

[8] Southern Med Univ, Dept Tradit Chinese Med, Nanfang Hosp, 1838 North Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2019年 / 6卷 / 05期

基金：

中国国家自然科学基金;

关键词：

RECEPTOR ENCEPHALITIS; ICAM-1; ISOFORM; L-SELECTIN; BRAIN; EXPRESSION; DISEASE; GENE; CSF;

D O I：

10.1002/acn3.740

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Increasing evidence indicates that immune system dysfunction affects anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. This study aims to investigate the relationship between adhesion molecules and the pathophysiology in anti-NMDAR encephalitis. Soluble forms of Intercellular adhesion molecule-1 (sICAM-1), vascular adhesion molecule-1 (sVCAM-1), and L-selectin (sL-selectin), were measured in the CSF and serum of 26 participants with anti-NMDAR encephalitis, 11 patients with schizophrenia and 22 patients with noninflammatory disorders. CSF levels of sICAM-1, sVCAM-1 and sL-selectin were significantly elevated in the anti-NMDAR encephalitis group. sVCAM-1 levels were positively associated with modified Rankin scale score in anti-NMDAR encephalitis patients at the onset and 3-month follow-up.

引用

页码：945 / 953

页数：9

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