Deep learning robotic guidance for autonomous vascular access

被引:107
作者
Chen, Alvin I. [1 ]
Balter, Max L. [1 ]
Maguire, Timothy J. [1 ]
Yarmush, Martin L. [1 ]
机构
[1] Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ 08854 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
PERIPHERAL VENOUS ACCESS; ULTRASOUND GUIDANCE; COMPLICATIONS; CARE; 3D; TISSUES; DEVICE; LEVEL; TIME; SKIN;
D O I
10.1038/s42256-020-0148-7
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
Medical robots have demonstrated the ability to manipulate percutaneous instruments into soft tissue anatomy while working beyond the limits of human perception and dexterity. Robotic technologies further offer the promise of autonomy in carrying out critical tasks with minimal supervision when resources are limited. Here, we present a portable robotic device capable of introducing needles and catheters into deformable tissues such as blood vessels to draw blood or deliver fluids autonomously. Robotic cannulation is driven by predictions from a series of deep convolutional neural networks that encode spatiotemporal information from multimodal image sequences to guide real-time servoing. We demonstrate, through imaging and robotic tracking studies in volunteers, the ability of the device to segment, classify, localize and track peripheral vessels in the presence of anatomical variability and motion. We then evaluate robotic performance in phantom and animal models of difficult vascular access and show that the device can improve success rates and procedure times compared to manual cannulations by trained operators, particularly in challenging physiological conditions. These results suggest the potential for autonomous systems to outperform humans on complex visuomotor tasks, and demonstrate a step in the translation of such capabilities into clinical use. Getting safe and fast access to blood vessels is vital to many methods of treatment and diagnosis in medicine. Robot-assisted or even fully autonomous methods can potentially do the task more reliably than humans, especially when veins are hard to detect. In this work, a method is tested that uses deep learning to find blood vessels and track the movement of a patient's arm.
引用
收藏
页码:104 / +
页数:17
相关论文
共 74 条
[1]  
Abadi M, 2016, ACM SIGPLAN NOTICES, V51, P1, DOI [10.1145/2951913.2976746, 10.1145/3022670.2976746]
[2]  
[Anonymous], 2015, Tiny ImageNet Visual Recognition Challenge., DOI DOI 10.1109/ICCV.2015.123
[3]   Clinical applications of robotic technology in vascular and endovascular surgery [J].
Antoniou, George A. ;
Riga, Celia V. ;
Mayer, Erik K. ;
Cheshire, Nicholas J. W. ;
Bicknell, Colin D. .
JOURNAL OF VASCULAR SURGERY, 2011, 53 (02) :493-499
[4]   Prevalence of difficult venous access and associated risk factors in highly complex hospitalised patients [J].
Armenteros-Yeguas, Victoria ;
Garate-Echenique, Lucia ;
Aranzazu Tomas-Lopez, Maria ;
Cristobal-Dominguez, Estibaliz ;
Moreno-de Gusmao, Breno ;
Miranda-Serrano, Erika ;
Inmaculada Moraza-Dulanto, Maria .
JOURNAL OF CLINICAL NURSING, 2017, 26 (23-24) :4267-4275
[5]   Automated end-to-end blood testing at the point-of-care: Integration of robotic phlebotomy with downstream sample processing [J].
Balter, M. L. ;
Leipheimer, J. M. ;
Chen, A. I. ;
Shrirao, A. ;
Maguire, T. J. ;
Yarmush, M. L. .
TECHNOLOGY, 2018, 6 (02) :59-66
[6]   Adaptive Kinematic Control of a Robotic Venipuncture Device Based on Stereo Vision, Ultrasound, and Force Guidance [J].
Balter, Max L. ;
Chen, Alvin I. ;
Maguire, Timothy J. ;
Yarmush, Martin L. .
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS, 2017, 64 (02) :1626-1635
[7]   Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm [J].
Bashkatov, AN ;
Genina, EA ;
Kochubey, VI ;
Tuchin, VV .
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2005, 38 (15) :2543-2555
[8]   Clutter filter design for ultrasound color flow imaging [J].
Bjærum, S ;
Torp, H ;
Kirstoffersen, K .
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 2002, 49 (02) :204-216
[9]  
Bradski G, 2000, DR DOBBS J, V25, P120
[10]  
Brewer R., 2015, "Improving peripheral iv catheterization through robotics: From simple assistive devices to a fully-autonomous system