Macronutrients and the Adipose-Liver Axis in Obesity and Fatty Liver

被引：82

作者：

Duwaerts, Caroline C.

Maher, Jacquelyn J.

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[2] Univ Calif San Francisco, Ctr Liver, San Francisco, CA 94143 USA

来源：

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY | 2019年 / 7卷 / 04期

关键词：

Carbohydrate; Fat; Metabolism; Diet; Fatty Liver Disease; ENDOPLASMIC-RETICULUM STRESS; TUMOR-NECROSIS-FACTOR; GLUCOSE-SWEETENED BEVERAGES; INDUCED INSULIN-RESISTANCE; CHOLINE-DEFICIENT MODEL; DIETARY SATURATED FAT; DE-NOVO LIPOGENESIS; HEPATIC STEATOSIS; URIC-ACID; GENE-EXPRESSION;

D O I：

10.1016/j.jcmgh.2019.02.001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Macronutrient metabolism is a highly orchestrated process, with adipose tissue and liver each playing central roles in nutrient uptake, processing, transport, and storage. These 2 tissues form an important metabolic circuit, particularly as it relates to lipids as the primary storage form of excess energy. The function of the circuit is influenced by many factors, including the quantity and type of nutrients consumed and their impact on the overall health of the tissues. In this review we begin with a brief summary of the homeostatic disposition of lipids between adipose tissue and liver and how these processes can become dysregulated in obesity. We then explore how specific dietary nutrients and nutrient combinations can exert unique influences on the liver-adipose tissue axis.

引用

收藏

页码：749 / 761

页数：13

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