Impact of Obesity on Cardiovascular Disease

被引：102

作者：

Zalesin, Kerstyn C. ^{[1
]}

Franklin, Barry A. ^{[2
]}

Miller, Wendy M. ^{[3
]}

Peterson, Eric D. ^{[4
]}

McCullough, Peter A. ^{[1
]}

机构：

[1] William Beaumont Hosp, Dept Med, Div Nutr & Preventat Med, Royal Oak, MI 48073 USA

[2] William Beaumont Hosp, Cardiac Rehabil & Exercise Labs, Royal Oak, MI 48073 USA

[3] William Beaumont Hosp, Weight Control Ctr, Div Nutr & Preventat Med, Royal Oak, MI 48073 USA

[4] Duke Univ, Sch Med, Duke Clin Res Inst, Durham, NC 27705 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2008年 / 37卷 / 03期

关键词：

D O I：

10.1016/j.ecl.2008.06.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The epidemiology of cardiovacular disease risk factors is changing rapidly with the obesity pandemic. Obesity is independently associated with the risks for coronary heart disease, atrial fibrillation, and heart failure. Intra-abdominal obesity is also unique as a cardiovascular risk state in that it contributes to or directly causes most other modifiable risk factors, namely, hypertension, dysmetabolic syndrome, and type 2 diabetes mellitus. Obesity can also exacerbate cardiovascular disease through a variety of mechanisms including systemic inflammation, hypercoagulability, and activation of the sympathetic and reninangiotensin systems. Thus, weight reduction is a key strategy for simultaneous improvement in global cardiovascular risk, with anticipated improvements in survival and quality of life.

引用

页码：663 / +

页数：23

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