Ocriplasmin for Vitreoretinal Diseases

被引：13

作者：

Tsui, Irena ^{[1
]}

Pan, Carolyn K. ^{[1
]}

Rahimy, Ehsan ^{[1
]}

Schwartz, Steven D. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Retina Div, Jules Stein Eye Inst, Los Angeles, CA 90095 USA

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2012年

关键词：

PLASMIN-ASSISTED VITRECTOMY; ENDOGENOUS MATRIX METALLOPROTEINASE-2; POSTERIOR VITREOUS DETACHMENT; VITREOMACULAR TRACTION SYNDROME; INTERNAL LIMITING MEMBRANE; DIABETIC MACULAR EDEMA; AUTOLOGOUS-PLASMIN; PHARMACOLOGICAL VITREOLYSIS; INTRAVITREAL PLASMIN; HUMAN-EYE;

D O I：

10.1155/2012/354979

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Fibronectin and laminin are clinically relevant plasmin receptors in the eye. Located at the vitreoretinal interface, they are cleaved by ocriplasmin (Microplasmin, ThromboGenics, Iselin, NJ), a novel ophthalmic medication. A series of clinical trials to study ocriplasmin for the treatment of vitreoretinal diseases such as vitreomacular traction, macular hole, and exudative age-related macular degeneration are underway. The results are promising and may impact patient care.

引用

页数：6

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