In vivo brain myo-inositol levels in children with Down syndrome

被引：32

作者：

Berry, GT

Wang, ZYJ

Dreha, SF

Finucane, BM

Zimmerman, RA

机构：

[1] Childrens Hosp Philadelphia, Div Endocrinol Diabet & Genet, Abramson Pediat Res Ctr, Dept Radiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Pediat, Div Endocrinol Diabet & Genet, Philadelphia, PA 19104 USA

[3] Elwyn Inc, Elwyn, PA USA

来源：

JOURNAL OF PEDIATRICS | 1999年 / 135卷 / 01期

关键词：

D O I：

10.1016/S0022-3476(99)70334-3

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The Na+/myo-inositol cotransporter (SLC5A3) gene, located on the long arm of human chromosome 21, may play a key role in osmoregulation including the regulation of levels of the "idiogenic osmole," myo-inositol, in brain cells. To determine whether the levels of myo-inositol are increased in the basal ganglia of children with Down syndrome, we performed in vivo brain hydrogen 1-nuclear magnetic resonance or H-1-magnetic resonance spectroscopy and measured plasma osmolality in a cohort of children with trisomy 21. Myo-inositol is elevated in the corpus striatum of infants and children with Down syndrome, even in the absence of hypertonic stress.

引用

页码：94 / 97

页数：4

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