Reciprocal Cross Talk between Fatty Acid and Antibiotic Biosynthesis in a Nematode Symbiont

被引：31

作者：

Brachmann, Alexander O. ^{[1
]}

Reimer, Daniela ^{[1
]}

Lorenzen, Wolfram ^{[1
]}

Alonso, Eduardo Augusto ^{[1
]}

Kopp, Yannick ^{[1
]}

Piel, Joern ^{[2
,3
]}

Bode, Helge B. ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Mol Biowissensch, D-60438 Frankfurt, Germany

[2] Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany

[3] ETH, Inst Microbiol, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 48期

关键词：

biosynthesis; fatty acids; natural products; primary metabolism; secondary metabolism; SECONDARY METABOLISM; GENE-CLUSTER; STREPTOMYCES-VIRGINIAE; STARTER-UNIT; DIVERSITY; BACTERIA;

D O I：

10.1002/anie.201205384

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Don't play the second fiddle! The identification of different arrangements of branched-chain keto acid dehydrogenases usually involved in the biosynthesis of cellular building blocks is demonstrated (see scheme). Direct cross talk between secondary metabolism ketosynthases (KS) and fatty acid biosynthesis is shown and the biosynthesis of odd-numbered iso-fatty acids is found to be connected to the production of pristinamycin IIa. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：12086 / 12089

页数：4

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