Intermittent preventive antimalarial treatment to children (IPTc): firebreak or fire trap?

被引：4

作者：

Buffet, Pierre A. ^{[1
,2
,3
]}

Briand, Valerie ^{[4
]}

Renia, Laurent ^{[5
]}

Thellier, Marc ^{[1
,2
,3
]}

Danis, Martin ^{[1
,2
,3
]}

Mazier, Dominique ^{[1
,2
,3
]}

机构：

[1] INSERM, UMR S511, F-75013 Paris, France

[2] Univ Paris 06, UMR S511, F-75013 Paris, France

[3] Grp Hosp Pitie Salpetriere, AP HP, Serv Parasitol Mycol, F-75013 Paris, France

[4] Inst Rech Dev, UR010, Paris, France

[5] ASTAR, Biopolis, Lab Malaria Immunobiol, Singapore Immunol Network, Singapore, Singapore

来源：

TRENDS IN PARASITOLOGY | 2008年 / 24卷 / 11期

关键词：

D O I：

10.1016/j.pt.2008.07.007

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Intermittent preventive treatment is the prescheduled administration of antimalarial drugs to at-risk patients in endemic areas. This approach, which is recommended for pregnant women, is being evaluated in children. Sulfadoxine-pyrimethamine plus amodiaquine recently proved to be more protective than artemisinin-containing regimens. Therefore, the use of artemisinin derivatives could potentially be restricted to symptomatic patients. Determinants of three pending issues: safety, efficacy throughout childhood, and effectiveness - the latter depending on the implementation of sustainable delivery mechanisms - are analyzed in this comment.

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页码：482 / 485

页数：4

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