Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis

被引：121
作者：
Labidi-Galy, Sana Intidhar [1 ,2 ,3 ,4 ,5 ,6 ]
Treilleux, Isabelle [7 ]
Goddard-Leon, Sophie [7 ]
Combes, Jean-Damien [8 ]
Blay, Jean-Yves [1 ,2 ,3 ,4 ,5 ,6 ]
Ray-Coquard, Isabelle [6 ]
Caux, Christophe [1 ,2 ,3 ,4 ,5 ]
Bendriss-Vermare, Nathalie [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Lyon, Lyon, France
[2] Univ Lyon 1, ISPB, F-69365 Lyon, France
[3] INSERM, U1052, Ctr Rech Cancerol Lyon, F-69008 Lyon, France
[4] CNRS, UMR5286, Ctr Rech Cancerol Lyon, Lyon, France
[5] LabEx DEVweCAN, Lyon, France
[6] Ctr Leon Berard, Dept Med Oncol, F-69373 Lyon, France
[7] Ctr Leon Berard, Dept Biopathol, F-69373 Lyon, France
[8] Ctr Leon Berard, Dept Biostat, F-69373 Lyon, France
来源：
ONCOIMMUNOLOGY | 2012年 / 1卷 / 03期
关键词：
plasmacytoid dendritic cell; ovarian cancer; immune tolerance; prognosis; progression-free survival; CHRONIC MYELOID-LEUKEMIA; IMATINIB;
D O I：
10.4161/onci.18801
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Using two different and complementary approaches (flow cytometry and immunohistochemistry) on two independent cohorts of ovarian cancer patients, we found that accumulation of plasmacytoid dendritic cells (pDC) in tumors is associated with early relapse. This deleterious effect of tumor-associated pDC was evident when they are present in cancer epithelium but not in lymphoid aggregates.
引用
收藏
页码：379 / 381
页数：3
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